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TitleDynamic piezoelectric stimulation enhances osteogenic differentiation of human adipose stem cells
Author(s)Ribeiro, Clarisse Marta Oliveira
Pärssinen, J.
Sencadas, Vítor João Gomes Silva
Correia, Vítor Manuel Gomes
Miettinen, S.
Hytönen, V. P.
Lanceros-Méndez, S.
KeywordsElectroactive polymer
Stem cell
Dynamic condition
dynamic conditions
Issue date2015
JournalJournal of Biomedical Materials Research Part A
Abstract(s)This work reports on the influence of the substrate polarization of electroactive β-PVDF on human adipose stem cells (hASCs) differentiation under static and dynamic conditions. hASCs were cultured on different β-PVDF surfaces (non-poled and “poled -”) adsorbed with fibronectin and osteogenic differentiation was determined using a quantitative alkaline phosphatase assay. “Poled -” β-PVDF samples promote higher osteogenic differentiation, which is even higher under dynamic conditions. It is thus demonstrated that electroactive membranes can provide the necessary electromechanical stimuli for the differentiation of specific cells and therefore will support the design of suitable tissue engineering strategies, such as bone tissue engineering.
AccessOpen access
Appears in Collections:CDF - FCD - Artigos/Papers (with refereeing)

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