Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/38634

TítuloCompact saloplastic membranes of natural polysaccharides for soft tissue engineering
AutorCosta, Rui R.
Costa, A. M. S.
Caridade, S. G.
Mano, J. F.
Palavras-chaveComplexation
Natural polyelectrolytes
Saloplastics
Soft tissues
DataOut-2015
EditoraAmerican Chemical Society
CitaçãoCosta R. R., Costa A. M. S., Caridade S. G., Mano J. F. Compact Saloplastic Membranes of Natural Polysaccharides for Soft Tissue Engineering, Chemistry of Materials, Vol. 27, Issue 21, pp. 7490-7502, doi:10.1021/acs.chemmater.5b03648, 2015
ResumoThe regeneration of soft biological tissues requires new substitutes that exhibit mechanical properties similar to the native tissue. Herein, thin saloplastic membranes with tunable physical properties are prepared by complexation of chitosan and alginate solutions containing different concentrations of sodium chloride. Polyelectrolyte complexes (PECs) are transferred to flat Petri dishes for compaction into membrane shapes by sedimentation and solvent evaporation. All membranes are resistant to degradation by lysozyme and are stable in solutions with pH values between 1 and 13. Immersing the different membranes in new doping solutions of increasing salt concentrations triggers the typical saloplastic behavior, with a high water absorption and decrease of the rigidity and ultimate tensile strength. The range of such variations is tuned by the sodium chloride amount used in the synthesis: high salt concentrations increase water uptake and tensile moduli, while decreasing the ultimate strength. Cellular assays demonstrate high proliferation rates and viability of L929 fibroblasts seeded onto the most rigid membranes. The results validate the use of saloplastic membranes as soft tissue substitutes for future biomedical applications.
Tipoarticle
URIhttp://hdl.handle.net/1822/38634
DOI10.1021/acs.chemmater.5b03648
ISSN0897-4756
1520-5002
Versão da editorahttp://pubs.acs.org/doi/abs/10.1021/acs.chemmater.5b03648
Arbitragem científicayes
AcessorestrictedAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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