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TitleMagnetically multilayer polysaccharide membranes for biomedical applications
Author(s)Gil, Sara
Silva, Joana M.
Mano, J. F.
Magnetic field
Magnetic responsive
Shape memory
Smart nanocomposites
Tissue engineering
Issue dateAug-2015
PublisherAmerican Chemical Society
JournalACS Biomaterials Science and Engineering
CitationGil S., Silva J. M., Mano J. F. Magnetically Multilayer Polysaccharide Membranes for Biomedical Applications, ACS Biomaterials Science and Engineering, doi:DOI: 10.1021/acsbiomaterials.5b00292, 2015
Abstract(s)Self-standing nanocomposite films based on biopolymers and functional nanostructures have been widely used due to their potential applications as active elements in biomedical devices. The coupling between chitosan (CHI) and alginate (ALG) multilayered films and magnetic nanoparticles (MNPs) allowed to fabricate magnetic responsive freestanding membranes with a high structural control along the thickness, using the layer-by-layer (LbL) methodology. The mechanical characterization evidenced a trend for an increase of both Young modulus, and ultimate tensile strength with the inclusion of MNPs, or by cross-linking with genipin. Additionally, the multilayered membranes exhibited shape memory properties triggered by hydration. The in vitro biological performance studies showed that cells were more viable and adherent with higher proliferation rates when MNPs were included in the membranes. Our results suggested the potential of the developed magneto-active freestanding membranes for biomedical applications, such as in tissue engineering and biomedical applications.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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