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https://hdl.handle.net/1822/36841
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Campo DC | Valor | Idioma |
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dc.contributor.author | Keller, Luiz | por |
dc.contributor.author | Abrunhosa, Luís | por |
dc.contributor.author | Keller, Kelly | por |
dc.contributor.author | Rosa, Carlos Alberto | por |
dc.contributor.author | Cavaglieri, Lilia | por |
dc.contributor.author | Venâncio, Armando | por |
dc.date.accessioned | 2015-09-04T09:24:30Z | - |
dc.date.available | 2015-09-04T09:24:30Z | - |
dc.date.issued | 2015-08 | - |
dc.date.submitted | 2015-07 | - |
dc.identifier.citation | Keller, Luiz; Abrunhosa, Luís; Keller, Kelly; Rosa, Carlos Alberto; Cavaglieri, Lilia; Venâncio, Armando, Zearalenone and its derivatives α-Zearalenol and β-zearalenol decontamination by Saccharomyces cerevisiae strains isolated from bovine forage. Toxins, 7(8), 3297-3308, 2015 | por |
dc.identifier.issn | 2072-6651 | por |
dc.identifier.uri | https://hdl.handle.net/1822/36841 | - |
dc.description.abstract | Zearalenone (ZEA) and its derivatives are mycotoxins with estrogenic effects on mammals. The biotransformation for ZEA in animals involves the formation of two major metabolites, - and -zearalenol (-ZOL and -ZOL), which are subsequently conjugated with glucuronic acid. The capability of Saccharomyces cerevisiae strains isolated from silage to eliminate ZEA and its derivatives -ZOL and -ZOL was investigated as, also, the mechanisms involved. Strains were grown on Yeast Extract-Peptone-Dextrose medium supplemented with the mycotoxins and their elimination from medium was quantified over time by HPLC-FL. A significant effect on the concentration of ZEA was observed, as all the tested strains were able to eliminate more than 90% of the mycotoxin from the culture medium in two days. The observed elimination was mainly due to ZEA biotransformation into -ZOL (53%) and -ZOL (8%) rather than to its adsorption to yeast cells walls. Further, the biotransformation of -ZOL was not observed but a small amount of -ZOL (6%) disappeared from culture medium. ZEA biotransformation by yeasts may not be regarded as a full detoxification process because both main end-products are still estrogenic. Nonetheless, it was observed that the biotransformation favors the formation of -ZOL which is less estrogenic than ZEA and -ZOL. This metabolic effect is only possible if active strains are used as feed additives and may play a role in the detoxification performance of products with viable S. cerevisiae cells. | por |
dc.description.sponsorship | Grants from CYTED, CNPq, CAPES-DS, and FAPUR/UFRRJ (Brazil). This work was also funded by FEDER funds through the “Programa Operacional Factores de Competitividade-COMPETE” and by national funds through “Fundação para a Ciência e a Tecnologia -FCT”, Ref. FCOMP-01-0124-F EDER-028029 and PTDC/AGR-TEC/3900/2012,respectively. FCT Strategic Project PEst-OE/EQB/LA0023/2013 and the Project “BioInd - Biotechnology and Bioengineering for improved Indus trial and Agro-Food processes, REF. NORTE-07-0124-FEDER-000028” Co-funded by the Programa Operacional Regional do Norte (ON.2-O Novo Norte), QREN, FEDER. Grant Incentivo/EQB/LA0023/2014 from ON.2-O Novo Norte. | por |
dc.language.iso | eng | por |
dc.publisher | MDPI Publishing | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/130482/PT | - |
dc.rights | openAccess | por |
dc.subject | ZEA | por |
dc.subject | α-ZOL | por |
dc.subject | β-ZOL | por |
dc.subject | Detoxification | por |
dc.subject | Adsorption | por |
dc.subject | Saccharomyces cerevisiae | por |
dc.subject | ß-ZOL | por |
dc.title | Zearalenone and its derivatives α-Zearalenol and β-Zearalenol decontamination by Saccharomyces cerevisiae strains isolated from bovine forage | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.mdpi.com/2072-6651/7/8/3297 | por |
dc.comments | CEB22343 | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 3297 | por |
oaire.citationEndPage | 3308 | por |
oaire.citationIssue | 8 | por |
oaire.citationTitle | Toxins | por |
oaire.citationVolume | 7 | por |
dc.date.updated | 2015-08-28T09:43:21Z | - |
dc.identifier.eissn | 2072-6651 | - |
dc.identifier.doi | 10.3390/toxins7083297 | por |
dc.identifier.pmid | 26308051 | por |
dc.subject.fos | Ciências Naturais::Ciências Biológicas | por |
dc.subject.fos | Ciências Agrárias::Biotecnologia Agrária e Alimentar | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Toxins | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_22343_1.pdf | 580,58 kB | Adobe PDF | Ver/Abrir |