Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/36163

TitleCharacterization of a new genetic environment associated with GES-6 carbapenemase from a Pseudomonas aeruginosa isolate belonging to the high-risk clone ST235
Author(s)Botelho, J.
Grosso, F.
Sousa, Clara Cecília Santana
Peixe, L.
Keywordscarbapenem resistance
class I integrons
ISPa55
IS110 family
site-specific recombination
Issue date2015
PublisherOxford University Press
JournalJournal of Antimicrobial Chemotherapy
CitationBotelho, J.; Grosso, F.; Sousa, C.; Peixe, L., Characterization of a new genetic environment associated with GES-6 carbapenemase from a Pseudomonas aeruginosa isolate belonging to the high-risk clone ST235. Journal of Antimicrobial Chemotherapy, 70(2), 615-617, 2015
Abstract(s)Pseudomonas aeruginosa is an opportunistic pathogen commonly associated with nosocomial infections.1 The spread of P. aeruginosa strains resistant to carbapenems constitutes an emerging threat worldwide.1 The GES family of enzymes has been identified in several Gram-negative bacteria, such as P. aeruginosa, Klebsiella pneumoniae and Escherichia coli, being responsible for an extended resistance spectrum to several -lactams.2,3 To date, according to the Lahey Clinic web site (http://www.lahey.org/Studies/), 24 variants of GES have been identified with some presenting carbapenemase activity, which is a matter of great concern. Few GES variants have been identified in Portugal, all of them found in Enterobacteriaceae.3 In Portugal, carbapenemases associated with P. aeruginosa include VIM-2 (the most frequent) and also IMP-5.4 Here, we report the first known worldwide description of the blaGES-6 gene in P. aeruginosa strains associated with a new genetic environment and also the first description of GES-producing P. aeruginosa in Portugal.
TypeLetter to the editor
URIhttp://hdl.handle.net/1822/36163
DOI10.1093/jac/dku391
ISSN1460-2091
e-ISSN0305-7453
Publisher versionhttp://jac.oxfordjournals.org/
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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