1. Universidade do Minho
  2. Escola de Engenharia | School of Engineering
  3. Centro de Engenharia Biológica | Centre of Biological Engineering
  4. CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series
Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/35305

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Campo DCValorIdioma
dc.contributor.authorLoureiro, Ana Isabel Sápor
dc.contributor.authorBernardes, Gonçalo J. L.por
dc.contributor.authorShimanovich, Ulyanapor
dc.contributor.authorSárria, M. P.por
dc.contributor.authorNogueira, Eugéniapor
dc.contributor.authorPreto, Anapor
dc.contributor.authorGomes, Andreia Cpor
dc.contributor.authorPaulo, Artur Cavacopor
dc.date.accessioned2015-05-27T11:22:44Z-
dc.date.available2015-05-27T11:22:44Z-
dc.date.issued2015-07-
dc.date.submitted2015-01-
dc.identifier.citationLoureiro, Ana; Bernardes, Gonçalo J. L.; Shimanovich, Ulyana; Sárria, M. P.; Nogueira, Eugénia; Preto, Ana; Gomes, Andreia C.; Paulo, Artur Cavaco, Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors. Nanomedicine: Nanotechnology, Biology, and Medicine, 11(5), 1077-1083, 2015por
dc.identifier.issn1549-9634por
dc.identifier.urihttps://hdl.handle.net/1822/35305-
dc.description.abstractFolic Acid (FA)-tagged protein nanoemulsions were found to be preferentially internalized on B-cell lymphoma cell line (A20 cell line), which, for the first time, are reported to express folate receptor (FR)-alpha. Carbon monoxide releasing molecule-2 (CORM-2) was incorporated in the oil phase of the initial formulation. FA-functionalized nanoemulsions loaded with CORM-2 exhibited a considerable antitumor effect and an increased survival of BALB/c mice bearing subcutaneous A20 lymphoma tumors. The developed nanoemulsions also demonstrated to be well tolerated by these immunocompetent mice. Thus, the results obtained in this study demonstrate that FA-tagged protein nanoemulsions can be successfully used in cancer therapy, with the important ability to delivery drugs intracellularly.por
dc.description.sponsorshipSFRH/BD/81479/2011 and SFRH/BD/81269/2011 scholarships from Fundação para a Ciência e a Tecnologia (FCT). This work has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement NMP4-LA-2009-228827 NANOFOL. This work was supported by FEDER through POFC-COMPETE and by Portuguese funds from FCT through the project PEst-OE/BIA/UI4050/2014.por
dc.language.isoengpor
dc.publisherElsevier B.V.por
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/228827/EU-
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FBIA%2FUI4050%2F2014/PT-
dc.rightsopenAccesspor
dc.subjectProtein nanoemulsionspor
dc.subjectFolic acidpor
dc.subjectCORM-2por
dc.subjectSpecific uptakepor
dc.subjectTargeted drug deliverypor
dc.titleFolic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumorspor
dc.typearticle-
dc.peerreviewedyespor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1549963415000726por
dc.commentsCEB19878por
sdum.publicationstatuspublishedpor
oaire.citationStartPage1077por
oaire.citationEndPage1083por
oaire.citationIssue5por
oaire.citationConferencePlaceNetherlands-
oaire.citationTitleNanomedicine: Nanotechnology, Biology and Medicinepor
oaire.citationVolume11por
dc.date.updated2015-05-27T06:38:04Z-
dc.identifier.eissn1549-9642-
dc.identifier.doi10.1016/j.nano.2015.02.022por
dc.identifier.pmid25791804por
dc.subject.fosCiências Médicas::Biotecnologia Médicapor
dc.subject.wosScience & Technologypor
sdum.journalNanomedicine: Nanotechnology, Biology, and Medicinepor
Aparece nas coleções:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series
CBMA - Artigos/Papers
DBio - Artigos/Papers

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