Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/35093
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Gonçalves, Idalina | por |
dc.contributor.author | Botelho, C. M. | por |
dc.contributor.author | Teixeira, Ana | por |
dc.contributor.author | Abreu, Ana S. | por |
dc.contributor.author | Hilliou, L. | por |
dc.contributor.author | Carla Manuela Pereira Marinho da | por |
dc.contributor.author | Paulo, Artur Cavaco | por |
dc.date.accessioned | 2015-05-08T12:01:51Z | - |
dc.date.available | 2015-05-08T12:01:51Z | - |
dc.date.issued | 2015-05 | - |
dc.identifier.citation | Gonçalves, Idalina; Botelho, C. M.; Teixeira, Ana; Abreu, A. S.; Hilliou, L.; Silva, Carla; Paulo, Artur Cavaco, Antimicrobial lubricant formulations containing poly(hydroxybenzene)-trimethoprim conjugates synthesized by tyrosinase. Applied Microbiology and Biotechnology, 99(10), 4225-4235, 2015 | por |
dc.identifier.issn | 0175-7598 | por |
dc.identifier.uri | https://hdl.handle.net/1822/35093 | - |
dc.description.abstract | Poly(hydroxybenzene)-trimethoprim conjugates were prepared using methylparaben as substrate of the oxida- tive enzyme tyrosinase. MALDI-TOF MS analysis showed that the enzymatic oxidation of methylparaben alone leads to the poly(hydroxybenzene) formation. In the presence of tri- methoprim, the methylparaben tyrosinase oxidation leads poly(hydroxybenzene)-trimethoprim conjugates. All of these compounds were incorporated into lubricant hydroxyethyl cellulose/glycerol mixtures. Poly(hydroxybenzene)-trimetho- prim conjugates were the most effective phenolic structures against the bacterial growth reducing by 96 and 97 % of Escherichia coli and Staphylococcus epidermidis suspen- sions, respectively (after 24 h). A novel enzymatic strategy to produce antimicrobial poly(hydroxybenzene)-antibiotic conjugates is proposed here for a wide range of applications on the biomedical field. | por |
dc.description.sponsorship | The authors Idalina Gonçalves and Cláudia Botelho would like to acknowledge the NOVO project (FP7-HEALTH- 2011.2.3.1- 5) for funding. Loïc Hilliou acknowledges the financial support by FCT – Foundation for Science and Technology, Portugal (501100001871), through Grant PEst-C/CTM/LA0025/2013 - Strategic Project - LA 25 - 2013–2014, and by Programa Operacional Regional do Norte (ON.2) through the project BMatepro – Optimizing Materials and Processes^, with reference NORTE-07-0124-FEDER-000037 FEDER COMPETE. | por |
dc.language.iso | eng | por |
dc.publisher | Springer | por |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/278402/EU | - |
dc.rights | openAccess | por |
dc.subject | Methylparaben | por |
dc.subject | Trimethoprim | por |
dc.subject | Tyrosinase | por |
dc.subject | Poly(hydroxybenzene) | por |
dc.subject | Conjugates | por |
dc.subject | Antimicrobial | por |
dc.title | Antimicrobial lubricant formulations containing poly(hydroxybenzene)-trimethoprim conjugates synthesized by tyrosinase | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.springer.com/chemistry/biotechnology/journal/253 | por |
dc.comments | CEB19859 | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 4225 | por |
oaire.citationEndPage | 4235 | por |
oaire.citationIssue | 10 | por |
oaire.citationConferencePlace | Germany | - |
oaire.citationTitle | Applied microbiology and biotechnology | por |
oaire.citationVolume | 99 | por |
dc.date.updated | 2015-05-06T10:46:13Z | - |
dc.identifier.eissn | 1432-0614 | - |
dc.identifier.doi | 10.1007/s00253-015-6509-1 | por |
dc.identifier.pmid | 25761624 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Applied Microbiology and Biotechnology | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series IPC - Artigos em revistas científicas internacionais com arbitragem |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_19859_1.pdf | 702,83 kB | Adobe PDF | Ver/Abrir |