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https://hdl.handle.net/1822/34869
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Campo DC | Valor | Idioma |
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dc.contributor.author | Yan, Leping | por |
dc.contributor.author | Oliveira, Joaquim M. | por |
dc.contributor.author | Oliveira, Ana Leite | por |
dc.contributor.author | Reis, R. L. | por |
dc.date.accessioned | 2015-04-15T15:51:40Z | - |
dc.date.available | 2015-04-15T15:51:40Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Yan L. P., Oliveira J. M., Oliveira A. L., Reis R. L. Current Concepts and Challenges in Osteochondral Tissue Engineering and Regenerative Medicine, ACS Biomaterials Science & Engineering, doi:10.1021/ab500038y, 2015 | por |
dc.identifier.issn | 2373-9878 | por |
dc.identifier.uri | https://hdl.handle.net/1822/34869 | - |
dc.description | "Publication Date (Web): February 20, 2015" | por |
dc.description.abstract | In the last few years, great progress has been made to validate tissue engineering strategies in preclinical studies and clinical trials on the regeneration of osteochondral defects. In the preclinical studies, one of the dominant strategies comprises the development of biomimetic/bioactive scaffolds, which are used alone or incorporated with growth factors and/or stem cells. Many new trends are emerging for modulation of stem cell fate towards osteogenic and chondrogenic differentiations, but bone/cartilage interface regeneration and physical stimulus have been showing great promise. Besides the matrix-associated autologous chondrocyte implantation (MACI) procedure, the matrix-associated stem cells implantation (MASI) and layered scaffolds in acellular or cellular strategy are also applied in clinic. This review outlines the progresses at preclinical and clinical levels, and identifies the new challenges in osteochondral tissue engineering. Future perspectives are provided, e.g., the applications of extracellular matrix-like biomaterials, computer-aided design/manufacture of osteochondral implant and reprogrammed cells for osteochondral regeneration. | por |
dc.description.sponsorship | The authors thank the Portuguese Foundation for Science and Technology (FCT) through the projects TISSUE2TISSUE (PTDC/CTM/105703/2008) and OsteoCart (PTDC/CTM-BPC/115977/2009). We also acknowledge European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement REGPOT-CT2012-316331-POLARIS. L-P.Y. acknowledges the PhD scholarship from FCT (SFRH/BD/64717/2009). The FCT distinction attributed to J.M.O. and A.L.O. under the Investigator FCT program (IF/00423/2012) and (IF/00411/2013) are also greatly acknowledged. | por |
dc.language.iso | eng | por |
dc.publisher | American Chemical Society | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/105703/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/115977/PT | - |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/316331/EU | - |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F64717%2F2009/PT | - |
dc.rights | openAccess | por |
dc.subject | Osteochondral tissue engineering | por |
dc.subject | Layered scaffold | por |
dc.subject | Biomimetic | por |
dc.subject | Interface engineering | por |
dc.subject | Clinical trial | por |
dc.subject | Pluripotent stem cells | por |
dc.title | Current concepts and challenges in osteochondral tissue engineering and regenerative medicine | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://pubs.acs.org/doi/pdf/10.1021/ab500038y | por |
dc.comments | http://www.3bs.uminho.pt/node/18333 | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 183 | por |
oaire.citationEndPage | 200 | por |
oaire.citationIssue | 4 | por |
oaire.citationTitle | ACS biomaterials science & engineering | por |
oaire.citationVolume | 1 | por |
dc.date.updated | 2015-03-19T15:04:35Z | - |
dc.identifier.doi | 10.1021/ab500038y | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | ACS biomaterials science & engineering | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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18333-ab500038y.pdf | 1,89 MB | Adobe PDF | Ver/Abrir |