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TitleCurrent concepts: tissue engineering and regenerative medicine applications in the ankle joint
Author(s)Correia, Sandra I.
Pereira, H.
Silva-Correia, Joana
Dijk, C. N. Van
Mendes, João Espregueira
Oliveira, Joaquim M.
Reis, R. L.
Osteochondral lesions
Regenerative medicine
Tissue engineering
Issue date2014
PublisherRoyal Society
JournalJournal of The Royal Society Interface
CitationCorreia S. I., Pereira H., Silva-Correia J., Dijk C. N. Van., Espregueira-Mendes J. D., Oliveira J. M., Reis R. L. Current Concepts: Tissue Engineering and Regenerative Medicine Applications in the Ankle Joint, Journal of the Royal Society Interface, Vol. 11, Issue 92, doi:10.1098/rsif.2013.0784, 2014
Abstract(s)Tissue engineering and regenerative medicine (TERM) has caused a revolution in present and future trends of medicine and surgery. In different tissues, advanced TERM approaches bring new therapeutic possibilities in either general population as in young patients and high-level athletes, improving restoration of biological functions and rehabilitation. The mainstream components required to obtain a functional regeneration of tissues may include biodegradable scaffolds, drugs or growth factors and different cell types (either autologous or heterologous) that can be cultured in bioreactor systems (in vitro) prior implantation into the patient. Particularly in the ankle, that is subject of many different injuries (e.g. acute, chronic, traumatic, degenerative), there is still no definitive and feasible answer to “conventional” methods. This review aims to provide current concepts of TERM applications to ankle injuries under pre-clinical and/or clinical research applied to skin, tendon, bone and cartilage problems. A particular attention has been given to biomaterials design and scaffolds processing with potential use in osteochondral ankle lesions.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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