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TitleIsolation and characterization of a new Staphylococcus epidermidis broad-spectrum bacteriophage
Author(s)Melo, L. D. R.
Sillankorva, Sanna
Ackermann, H. W.
Kropinski, A. M.
Azeredo, Joana
Cerca, Nuno
Issue date2014
PublisherSociety for General Microbiology
JournalJournal of General Virology
CitationMelo, L. D. R.; Sillankorva, Sanna; Ackermann, H. -W.; Kropinski, A. M.; Azeredo, Joana; Cerca, Nuno, Isolation and characterization of a new Staphylococcus epidermidis broad-spectrum bacteriophage. Journal of General Virology, 95, 506-515, 2014
Abstract(s)Staphylococcus epidermidis is considered an important nosocomial pathogen, being very tolerant to the host immune system and antibiotherapy, particularly when in biofilms. Due to its high resistance, alternative antimicrobial strategies are under development. The use of bacteriophages is seen as an important strategy to combat pathogenic organisms. In this study, a S. epidermidis myovirus, SEP1, was isolated and characterized. The genome of this phage was sequenced and shown to be peripherally related to the Twortlikevirus genus. However when compared to other phages of this genus, it showed DNA sequence identities no greater than 58.2%. As opposed to other polyvalent viruses of the Twortlikevirus genus, SEP1 is highly specific to S. epidermidis strains. The good infectivity showed by this phage as well as its high lytic spectrum suggests that it might be a good candidate for therapeutic studies.
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Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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