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dc.contributor.authorVasconcelos, Mayron Alvespor
dc.contributor.authorArruda, Francisco Vassiliepe Sousapor
dc.contributor.authorSantos, Hélcio Silva dospor
dc.contributor.authorRodrigues, Adriano S.por
dc.contributor.authorBandeira, Paulo Nogueirapor
dc.contributor.authorAlbuquerque, Maria Rose Jane Ribeiropor
dc.contributor.authorCavada, Benildo Sousapor
dc.contributor.authorTeixeira, Edson Holandapor
dc.contributor.authorHenriques, Marianapor
dc.contributor.authorPereira, Maria Olíviapor
dc.identifier.citationVasconcelos, M. A.; Arruda, F. V. S.; Santos, Hélcio S.; Rodrigues, Adriano S.; Bandeira, Paulo N.; Albuquerque, Maria R. J. R.; Cavada, Benildo S.; Teixeira, Edson H.; Henriques, Mariana; Pereira, M. O., Effect of a casbane diterpene isolated from Croton nepetaefolius on the prevention and control of biofilms formed by bacteria and Candida species. Industrial Crops and Products, 61, 499-509, 2014por
dc.description.abstractThis study aimed to evaluate the effect of the compound 1,4-dihydroxy-2E,6E,12E-trien-5-one-casbane (CD1CN), a casbane diterpene isolated from Croton nepetaefolius stalks, on the biofilm formation or preformed biofilms of bacteria and yeasts. Minimum inhibitory concentration results showed that CD1CN inhibited the growth of single cultures of Staphylococcus aureus and Candida albicans at 125 and 500 g/mL, respectively, as well as dual cultures of S. aureus with C. albicans or Candida glabrata at 500 and 250 g/mL, respectively. In general, CD1CN reduced biofilm biomass when applied to preformed biofilms or when applied during the biofilm formation of single and dual cultures in concentrations ranging from 31.25 to 250 g/mL, depending on the culture. CD1CN was more effective in reducing the cfu of S. aureus in single and dual biofilms (62.5–250 g/mL) than that of Pseudomonas aeruginosa, although this reduction was also significant. For yeasts, CD1CN was generally more effective in reducing C. glabrata cfu in single or dual cultures when compared to C. albicans. SEM images of the dual-species biofilms confirmed these results. In conclusion, CD1CN could be an effective alternative to conventional antimicrobial agents against infectious biofilms, in particular those attributed to mixed cultures.por
dc.description.sponsorshipThis study was supported by the Coordenacao de Aperfeicomento de Pessoal de Nivel Superior (CAPES - Brazil) through the BEX NT 2052/11NT3 project managed by the Instituto de Biotecnologia e Bioengenharia-Centro de Engenharia Biologica (IBB-CEB) and Fundacao para a Ciencia e a Tecnologia (FCT - Portugal); by the European Community fund FEDER through the COMPETE Program under the auspices of Project PTDC/SAU-ESA/646091/2006/FCOMP-01-0124-FEDER-007480; and by Fundacao Cearense de Apoio ao Desenvolvimento Cientifico e Tecnologico (Funcap - Brazil) through the BPI-0067-00068.01.00/12 project. BSC and EHT are senior researchers of CNPq. Mr. David Martin helped with the English editing of the manuscript that was also revised by AJE (American Journal Experts).por
dc.publisherElsevier B.V.por
dc.subjectPolymicrobial infectionspor
dc.subjectCasbane diterpenepor
dc.titleEffect of a casbane diterpene isolated from Croton nepetaefolius on the prevention and control of biofilms formed by bacteria and Candida speciespor
oaire.citationTitleIndustrial Crops and Productspor
dc.subject.wosScience & Technologypor
sdum.journalIndustrial Crops and Productspor
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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