Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/31605
Título: | Synthetic and biogenic magnetite nanoparticles for tracking of stem cells and dendritic cells |
Autor(es): | Schwarz, S. Fernandes, Fabiana Sanroman, L. Hodenius, M. Lang, C. Himmelreich, U. Schmitz-Rode, T. Schueler, D. Hoehn, M. Zenke, M. Hieronymus, T. |
Palavras-chave: | Iron oxide nanoparticle Magnetosome Stem cell Dendritic cell Nanoparticle uptake Magnetic resonance imaging Cell tracking |
Data: | 2009 |
Editora: | Elsevier B.V. |
Revista: | Journal of Magnetism and Magnetic Materials |
Citação: | Schwarz, S.; Fernandes, Fabiana; Sanroman, L.; Hodenius, M.; Lang, C.; Himmelreich, U.; Schmitz-Rode, T.; Schueler, D.; Hoehn, M.; Zenke, M.; Hieronymus, T., Synthetic and biogenic magnetite nanoparticles for tracking of stem cells and dendritic cells. Journal of Magnetism and Magnetic Materials, 321(10), 1533-1538, 2009 |
Resumo(s): | Accurate delivery of cells to target organs is critical for success of cell-based therapies with stem cells or immune cells such as antigen-presenting dendritic cells (DC). Labeling with contrast agents before implantation provides a powerful means for monitoring cellular migration using magnetic resonance imaging (MRI). In this study, we investigated the uptake of fully synthesized or bacterial magnetic nanoparticles (MNPs) into hematopoietic Flt3+ stem cells and DC from mouse bone marrow. We show that (i) uptake of both synthetic and biogenic nanoparticles into cells endow magnetic activity and (ii) low numbers of MNP-loaded cells are readily detected by MRI. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/31605 |
DOI: | 10.1016/j.jmmm.2009.02.081 |
ISSN: | 0304-8853 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
document_18160_1.pdf Acesso restrito! | 2,18 MB | Adobe PDF | Ver/Abrir |