Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/31586

TitleProcessing and characterization of alpha-elastin electrospun membranes
Author(s)Araújo, J.
Padrão, Jorge
Silva, João P.
Dourado, Fernando
Correia, D. M.
Botelho, Gabriela
Ribelles, J. L. Gómez
Lanceros-Méndez, S.
Sencadas, Vítor João Gomes Silva
Issue date2014
PublisherSpringer Verlag
JournalApplied Physics A: Materials Science and Processing
CitationAraujo, J.; Padrão, J.; Silva, João P.; Dourado, Fernando; Correia, D.; Botelho, G.; Gómez Ribelles, J. L.; Lanceros-Méndez, S.; Sencadas, V., Processing and characterization of alpha-elastin electrospun membranes. Applied Physics A: Materials Science and Processing, 115(4), 1291-1298, 2014
Abstract(s)Elastin isolated from fresh bovine ligaments was dissolved in a mixture of 1,1,1,3,3,3-Hexafluoro-2-propanol and water were electrospun into fiber membranes under different processing conditions. Fiber mats of randomly and aligned fibers were obtained with fixed and rotating ground collectors and fibrils were composed by thin ribbons whose width depends on electrospinning conditions; fibrils with 721 nm up to 2.12 μm width were achieved. After cross-linking with glutaraldehyde, α-elastin can uptake as much as 1700 % of PBS solution and a slight increase on fiber thickness was observed. The glass transition temperature of electrospun fiber mats was found to occur at ˜80 °C. Moreover, α-Elastin showed to be a perfect elastomeric material, and no mechanical hysteresis was found in cycle mechanical measurements. The elastic modulus obtained for random and aligned fibers mats in a PBS solution was 330±10 kPa and 732±165 kPa, respectively. Finally, the electrospinning and cross-linking process does not inhibit MC-3T3-E1 cell adhesion. Cell culture results showed good cell adhesion and proliferation in the cross-linked elastin fiber mats.
TypeArticle
URIhttp://hdl.handle.net/1822/31586
DOI10.1007/s00339-013-7984-9
ISSN0947-8396
e-ISSN1432-0630
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series
CDF - FCD - Artigos/Papers (with refereeing)

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