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TitleUnveiling the intracellular trafficking of drug-loaded dendrimer nanoparticles in astrocytes
Author(s)Cerqueira, Susana R.
Chowdhury, Helena H.
Mano, J. F.
Oliveira, Joaquim M.
Sousa, Nuno
Zorec, Ribert
Reis, R. L.
Issue dateJul-2014
PublisherJohn Wiley and Sons
JournalJournal of Tissue Engineering and Regenerative Medicine
CitationCerqueira S. R., Chowdhury H. H., Mano J. F., Oliveira J. M., Sousa N., Zorec R., Reis R. L. Unveiling the intracellular trafficking of drug-loaded dendrimer nanoparticles in astrocytes, J Tissue Eng Regen Med, Vol. 8, Issue 1, pp. 39-206, doi:10.1002/term.1931, 2014
Abstract(s)Introduction: Multifunctional dendrimers are emerging as promising solutions to the current dilemma of drug delivery to the central nervous system (CNS). Herein, we are proposing the use of carboxymethylchito- san (CMCht)-grafted PAMAM dendrimer nanoparticles (NP) to provide a targeted and sustained methylprednisolone (MP) release to CNS cells. MP is widely used following neurotrauma and neuroinflammation, however its actions are accompanied by deleterious effects. Despite recent research on nanomedicine, basic knowledge on the interactions of NP with living systems is still sparse. Thus, the interaction of MP-NP with the astrocyte membrane and its intracellular trafficking were investigated using a new combination of techniques, namely patch-- clamp electrophysiology and live confocal imaging.
AccessOpen access
Appears in Collections:3B’s - Resumos em livros de atas de conferências - indexados no ISI Web of Science

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