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TitleUnderstanding cellular behaviour in early and late stage of MSD
Author(s)Ondrésik, M. M.
Correia, C.
Sousa, R. A.
Oliveira, J. M.
Reis, R. L.
Issue dateJun-2014
JournalJournal of Tissue Engineering and Regenerative Medicine
CitationOndrésik M. M., Correia C., Sousa R.A., Oliveira J. M., Reis R. L. Understanding cellular behaviour in early and late stage of MSD, Journal of Tissue Engineering and Regenerative Medicine, Vol. 8, pp. 412-412, doi:10.1002/term.1932, 2014
Abstract(s)Osteoarthritis (OA) is the most common joint disease worldwide with only limited treatment options1. It is believed that the thorough analyses of the disease on cellular and molecular base can lead us to the discovery of new targets, and to the development of new therapies. Thus, we have been working on the development of a 3D model of human OA knee cartilage. By this in vitro model, it is expected to gain a better understanding on the disease process. The two main aspects of our research are: (1) how the mechanical loading and (2) how the presence of pro-inflammatory cytokines, e.g. TNF-α and IL1-β affects the degenerative processes2,3. In the present study, we demonstrated the effect of the different cytokines on monolayer and tissue culture.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Resumos em livros de atas de conferências - indexados no ISI Web of Science

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