Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/30696

TitleMicrofluidic production of perfluorocarbon-alginate core-shell microparticles for ultrasound therapeutic applications
Author(s)Duarte, Ana Rita C.
Unal, Barts
Mano, J. F.
Reis, R. L.
Jensen, Klavs
KeywordsAlginate
Microfluidics
perfluorocarbon
ultrasound delivery
Issue dateSep-2014
PublisherACS
JournalLangmuir
Abstract(s)The fabrication of micrometer-sized core−shell particles for ultrasound-triggered delivery offers a variety of applications in medical research. In this work, we report the design and development of a glass capillary microfluidic system containing three concentric glass capillary tubes for the development of core−shell particles. The setup enables the preparation of perfluorocarbon-alginate core−shell microspheres in a single process, avoiding the requirement for further extensive purification steps. Core−shell microspheres in the range of 110−130 μm are prepared and are demonstrated to be stable up to 21 days upon immersion in calcium chloride solution or water. The mechanical stability of the particles is tested by injecting them through a 23 gauge needle into a polyacrylamide gel to mimic the tissue matrix. The integrity of the particles is maintained after the injection process and is disrupted after ultrasound exposure for 15 min. The results suggest that the perfluorcarbon-alginate microparticles could be a promising system for the delivery of compounds, such as proteins, peptides, and small-molecule drugs in ultrasound-based therapies.
TypeArticle
URIhttp://hdl.handle.net/1822/30696
DOI10.1021/la502822v
ISSN0743-7463
Publisher versionhttp://pubs.acs.org/doi/abs/10.1021/la502822v
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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