Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/30255

TitleBioresorbable ureteral stents from natural origin polymers
Author(s)Barros, Alexandre A.
Duarte, Antônio R. C.
Pires, R. A.
Lima, E.
Mano, J. F.
Reis, R. L.
Ludovico, Paula
Sampaio-Marques, Belém
KeywordsBioresorbable
Natural origin polymers
Ureteral stents
aerogel
hydrogel
natural polymers
bioresorbable polymers
kidney stones
supercritical fluid technology
aerogel/hydrogel
Issue date2015
PublisherWiley-Blackwell
JournalJournal of Biomedical Materials Research Part B
CitationBarros, A. A., Rita, A., Duarte, A. R. C., Pires, R. A., Sampaio-Marques, B., Ludovico, P., . . . Reis, R. L. (2015). Bioresorbable ureteral stents from natural origin polymers. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 103(3), 608-617. doi: 10.1002/jbm.b.33237
Abstract(s)In this work, stents were produced from natural originpolysaccharides. Alginate, gellan gum, and a blend ofthese with gelatin were used to produce hollow tube (stents)following a combination of templated gelation and criticalpoint carbon dioxide drying. Morphological analysis of thesurface of the stents was carried out by scanning electronmicroscopy. Indwelling time, encrustation, and stability ofthe stents in artificial urine solution was carried out up to 60days of immersion. In vitro studies carried out with simulatedurine demonstrated that the tubes present a high fluid uptakeability, about 1000%. Despite this, the materials are able tomaintain their shape and do not present an extensive swellingbehavior. The bioresorption profile was observed to behighly dependent on the composition of the stent and it canbe tuned. Complete dissolution of the materials may occurbetween 14 and 60 days. Additionally, no encrustation wasobserved within the tested timeframe. The ability to resistbacterial adherence was evaluated with Gram-positive Staphylococcus aureus and two Gram-negatives Escherichia coliDH5 alpha and Klebsiella oxytoca. For K. oxytoca, no differenceswere observed in comparison with a commercialstent (BiosoftVR duo, Porges), although, for S. aureus alltested compositions had a higher inhibition of bacterialadhesion compared to the commercial stents. In case ofE. coli, the addition of gelatin to the formulations reducedthe bacterial adhesion in a highly significant manner comparedto the commercial stents. The stents produced by thedeveloped technology fulfill the requirements for ureteralstents and will contribute in the development of biocompatible and bioresorbable urinary stents.
TypeArticle
URIhttp://hdl.handle.net/1822/30255
DOI10.1002/jbm.b.33237
ISSN1552-4973
Publisher versionhttp://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33237/pdf
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals
ICVS - Artigos em Revistas Internacionais com Referee

Files in This Item:
File Description SizeFormat 
18037-bioresorbable ureteral stents from natural origin polymers_jbmb33237.pdf495,61 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID