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TitleTunable nano-carriers from clicked glycosaminoglycan block copolymers
Author(s)Novoa-Carballal, R.
Silva, C.
Möller, Stephanie
Schnabelrauch, Matthias
Reis, R. L.
Pashkuleva, I.
KeywordsChondroitin sulfate
Growth factors
Interpolyelectrolyte complex
Poly(ethylene glycol)
Issue dateApr-2014
PublisherRoyal Society of Chemistry
JournalJournal of Materials Chemistry B
CitationNovoa-Carballal R., Silva C., Moller S., Schnabelrauch M., Reis R. L., Pashkuleva I. Tunable nano-carriers from clicked glycosaminoglycan block copolymers, Journal of Materials Chemistry B, doi:10.1039/C4TB00410H, 2014
Abstract(s)Oxime click reaction is used for the synthesis of diblock copolymers of polyethylene glycol (PEG) and glycosaminoglycans (GAG) with different molecular weight (Mw) and sulfation degree. The ability of these copolymers to carry positively charged proteins is evidenced by their assembly with poly-L-lysine as a model: interpolyelectrolyte complexes with tunable size at the nanometric scale (radius of 25-90 nm) and narrow distribution are described. We demonstrate that there is a critical Mw of GAG for the formation of stable complexes and that the sulfation degree determines the size of the nano-assemblies. Highly sulfated GAGs form the smallest complexes that are stable to at least 500 mM ionic strength: properties that are not usual for GAG interpolyelectrolyte complexes. The feasibility of the synthesised block copolymers as protein carriers is further evidenced by their complexation with fibroblast growth factor (FGF-2). The described assets of GAG block copolymers together with the intrinsic GAG properties as biorecognition and biodegradability open new opportunities in the design of selective encapsulation/release nanosystems with stealth PEG corona.
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Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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