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TitleProtein micro- and nano-capsules for biomedical applications
Author(s)Shimanovich, Ulyana
Bernardes, Gonçalo J. L.
Knowles, T. P. J.
Paulo, Artur Cavaco
Issue date2014
PublisherRoyal Society of Chemistry
JournalChemical Society Reviews
CitationChemical Society Reviews, 43(5), 1361-1371, 2014
Abstract(s)Micro- and nano-scale systems have emerged as important tools for developing clinically useful drug delivery systems. In this tutorial review, we discuss the exploitation of biomacromolecules for this purpose, focusing on proteins, polypeptides, nucleic acids and polysaccharides and mixtures thereof as potential building blocks for novel drug delivery systems. We focus on the mechanisms of formation of micro- and nano-scale protein-based capsules and shells, as well as on the functionalization of such structures for use in targeted delivery of bioactive materials. We summarise existing methods for protein-based capsule synthesis and functionalization and highlight future challenges and opportunities for delivery strategies based on biomacromolecules.
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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