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TitleThe current status of iPS cells in cardiac research and their potential for tissue engineering and regenerative medicine
Author(s)Martins, Ana M.
Vunjak-Novakovic, Gordana
Reis, R. L.
KeywordsCardiac differentiation
Cardiac disease models
Cardiac tissue engineering
Induced pluripotent stem cells
Patient-specific stem cells
Regenerative medicine
Issue dateJan-2014
JournalStem Cell Reviews and Reports
CitationMartins A. M., Vunjak-Novakovic G., Reis R. L. The Current Status of iPS Cells in Cardiac Research and Their Potential for Tissue Engineering and Regenerative Medicine, Stem Cell Reviews and Reports, doi:10.1007/s12015-013-9487-7, 2014
Abstract(s)The recent availability of human cardiomyocytes derived from induced pluripotent stem (iPS) cells opens new opportunities to build in vitro models of cardiac disease, screening for new drugs, and patient-specific cardiac therapy. Notably, the use of iPS cells enables studies in the wide pool of genotypes and phenotypes. We describe progress in reprogramming of induced pluripotent stem (iPS) cells towards the cardiac lineage/differentiation. The focus is on challenges of cardiac disease modeling using iPS cells and their potential to produce safe, effective and affordable therapies/applications with the emphasis of cardiac tissue engineering. We also discuss implications of human iPS cells to biological research and some of the future needs.
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Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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