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TitleNeuronal cells’ behavior on polypyrrole coated bacterial nanocellulose three-dimensional (3D) scaffolds
Author(s)Muller, Daliana
Silva, João P.
Rambo, C.
Barra, G.
Dourado, Fernando
Gama, F. M.
KeywordsBacterial cellulose
bacterial nanocellulose
neuronal cells
3D cell culture
nanofibrous scaffolds
Issue date2013
PublisherTaylor & Francis
JournalJournal of Biomaterials Science. Polymer Edition
Abstract(s)In this work, polypyrrole (PPy) was in situ polymerized onto the surface of bacterial nanocellulose (BNC) produced by Gluconacetobacter xylinus, by chemical oxidation in aqueous medium using ammonium persulfate. Composites (BNC/PPy) were produced with varying concentrations of pyrrole (Py). The produced BNC/PPy membranes were used as a template for the seeding of PC12 rat neuronal cells. Cell suspensions were directly seeded onto the surfaces of the BNC/PPy membranes. The Py concentration affected the behavior of neuronal cells that adhered and grew significantly more on BNC/PPy comparatively to BNC. Scanning electron microscopy (SEM) micrographs revealed that PC12 cells adhered on the surface of the BNC and BNC/PPy membranes. Conductive PPy coatings on nanofibers acting as an active interface for tissue engineering may be used to regulate cell activity through electrical stimulations.
AccessRestricted access (UMinho)
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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