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TitleStudies on the biocompatibility of bacterial cellulose
Author(s)Andrade, Fábia K.
Alexandre, Nuno
Amorim, Irina
Gartner, Fátima
Maurício, Ana Colette
Luís, Ana Lúcia
Gama, Miguel
KeywordsBacterial cellulose
Bacterial cellulose biocompatibility
Tissue engineering
Cell adhesion
Mechanical properties
Adhesion peptide Arg-Gly-Asp
Arteries and veins
Issue date2013
JournalJournal of bioactive and compatible polymers
Abstract(s)Bacterial cellulose was functionalized with a chimeric protein containing a cellulose-binding module and the adhesion peptide Arg-Gly-Asp. Small-diameter bacterial cellulose membranes were produced and subcutaneously implanted in sheep for 1–32 weeks. The implants triggered a biological response similar to other high surface-to-volume implants. There were no significant differences in the inflammation degree between the bacterial cellulose coated with the recombinant protein Arg-Gly-Asp–cellulose-binding module and the native bacterial cellulose. The implants were considered to be mildly irritating to the tissue compared to the negative control sample (expanded polytetrafluoroethylene). The analysis of the fluorescence microscopy revealed that, apart from increasing cell adhesion, the presence of Arg-Gly-Asp stimulated an even cell distribution, while the cells on the untreated bacterial cellulose seemed to form aggregates. Furthermore, the cells on the Arg-Gly-Asp–treated bacterial cellulose presented a more elongated morphology. Mechanical tests indicated that the small-diameter bacterial cellulose tubes were more elastic than the human arteries and veins.
AccessRestricted access (UMinho)
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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