Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/26896
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Senhorães, Nádia | - |
dc.contributor.author | Costa, A. Luísa | - |
dc.contributor.author | Silva, Deolinda | - |
dc.contributor.author | Proença, M. Fernanda R. P. | - |
dc.contributor.author | Dias, Alice | - |
dc.date.accessioned | 2013-12-11T13:53:18Z | - |
dc.date.available | 2013-12-11T13:53:18Z | - |
dc.date.issued | 2013-09-26 | - |
dc.date.submitted | 2013-08-07 | - |
dc.identifier.issn | 0040-4020 | por |
dc.identifier.uri | https://hdl.handle.net/1822/26896 | - |
dc.description.abstract | New and efficient methods for the synthesis of N1-substituted and C6-substitued adenines were developed from the easily accessible 5-aminoimidazole-4-carboxamidines. Condensation of these compounds with triethyl orthoformate led to the selective synthesis of the N1-substituted adenines. Regioselective preparation of C6-substituted adenines could be accomplished when the same precursors were combined with dimethylformamide diethyl acetal. These C6-substituted adenines could also be obtained from the N1-substituted adenines by Dimroth rearrangement in the presence of dimethyl amine. | por |
dc.description.sponsorship | The authors gratefully acknowledge the financial support by the University of Minho and Foundation for the Science and Technology (FCT, Portugal) through the Portuguese NMR network (PTNMR, Bruker Avance III 400-Univ. Minho), the Project F-COMP-01-0124-FEDER-COMPETE and a Ph.D. grant awarded to N.S. (SFRH/BD/73721/2010). | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.rights | restrictedAccess | por |
dc.subject | Adenine | por |
dc.subject | Imidazole | por |
dc.subject | Regioselective | por |
dc.subject | Carboxamidines | por |
dc.subject | Purine | por |
dc.title | N1- and C6-substituted adenines : a regioselective and efficient synthesis | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 10014 | por |
oaire.citationEndPage | 10021 | por |
oaire.citationIssue | 47 | por |
oaire.citationTitle | Tetrahedron | por |
oaire.citationVolume | 69 | por |
dc.identifier.doi | 10.1016/j.tet.2013.09.063 | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Tetrahedron | por |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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N1- and C6-substituted adenines- a regioselective and efficient synthesis_F.pdf Acesso restrito! | Documento principal | 356,61 kB | Adobe PDF | Ver/Abrir |