Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/25593
Título: | Nanostructured hollow tubes based on chitosan and alginate multilayers |
Autor(es): | Silva, Joana M. Duarte, Ana Rita C. Custódio, Catarina A. Sher, Praveen Neto, Ana I. Pinho, A. C. Marques de Fonseca, Jaime C. Reis, R. L. Mano, J. F. |
Palavras-chave: | Alginate Chitosan Layer-by-layer Tissue engineering Tubular structures |
Data: | 2014 |
Editora: | Wiley |
Revista: | Advanced Healthcare Materials |
Resumo(s): | The design and production of structures with nanometer-sized polymer fi lms based on layer-by-layer (LbL) are of particular interest for tissue engineering since they allow the precise control of physical and biochemical cues of implantable devices. In this work, a method is developed for the preparation of nanostructured hollow multilayers tubes combining LbL and template leaching. The aim is to produce hollow tubes based on polyelectrolyte multilayer fi lms with tuned physical-chemical properties and study their effects on cell behavior. The final tubular structures are characterized by differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), microscopy, swelling, and mechanical tests, including dynamic mechanical analysis (DMA) in physiological simulated conditions. It is found that more robust films could be produced upon chemical cross-linking with genipin. In particular, the mechanical properties confi rms the viscoelastic properties and a storage and young modulus about two times higher. The water uptake decreases from about 390% to 110% after the cross-linking. The biological performance is assessed in terms of cell adhesion, viability, and proliferation. The results obtained with the cross-linked tubes demonstrate that these are more suitable structures for cell adhesion and spreading. The results suggest the potential of these structures to boost the development of innovative tubular structures for tissue engineering approaches. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/25593 |
DOI: | 10.1002/adhm.201300265 |
ISSN: | 2192-2659 |
Versão da editora: | http://onlinelibrary.wiley.com/doi/10.1002/adhm.201300265/abstract |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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17657-adhm201300265.pdf | 2,01 MB | Adobe PDF | Ver/Abrir |