Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/25531
Título: | Hemocompatibility study of a bacterial cellulose/polyvinyl alcohol nanocomposite |
Autor(es): | Leitão, Alexandre F. Gupta, Swati Silva, João P. Reviakine, I. Gama, F. M. |
Palavras-chave: | Bacterial cellulose Biocompatibility Biomaterials Polyvinyl alcohol Platelets Hemocompatibility |
Data: | 2013 |
Editora: | Elsevier 1 |
Revista: | Colloids and Surfaces B: Biointerfaces |
Resumo(s): | Bacterial cellulose (BC) has been suggested to be a suitable biomaterial for the development of cardiovascular grafts. The combination of BC with polyvinyl alcohol (PVA) results in nanocomposites with improved properties. Surprisingly, there are very few studies on the BC–blood interaction. This is the focus of this paper. We present the first thorough assessment of the hemocompatibility of the BC/PVA nanocomposite. Whole blood clotting time, plasma recalcification, Factor XII activation, platelet adhesion and activation, hemolytic index and complement activation are all determined. The platelet activation profiles on BC and BC/PVA surfaces are comprehensively characterized. BC and BC/PVA outperformed ePTFE – used as a point of comparison – thus evidencing their suitability for cardiovascular applications. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/25531 |
DOI: | 10.1016/j.colsurfb.2013.06.031 |
ISSN: | 0927-7765 |
e-ISSN: | 0927-7765 |
Versão da editora: | www.elsevier.com/locate/colsurfb |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |