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TitleCistus ladanifer as a source of phenolic compounds with antifungal activity
Author(s)Barros, Lillian
Duenas, M.
Alves, Carlos
Silva, Sónia Carina
Henriques, Mariana
Santos-Buelga, Celestino
Ferreira, Isabel C. F. R.
Issue date2012
PublisherGeorg Thieme Verlag
JournalPlanta Medica
Abstract(s)A screening of the antifungal potential of phenolic extract of Cistus ladanifer from Northeast Portugal, against Candida species was performed. The extract was characterized by HPLC-DAD-ESI/MS. Phenolic acids and derivatives, ellagic acid derivatives and flavonoids, such as catechins, flavonols and flavones, were found in the sample, The most abudant group was ellagic acid derivatives in which punicalagin gallate, a derivative of punicalagin attached to gallic acid, was found in highest amount. These compounds could be related to the strong inhibition of C. albicans, C. glabrata and C. parapsilosis growth. Moreover, the best antifungal activity was against C. glabrata, where the studied extract was able to cause at least 3 Log of reduction at concentrations below 50μg/mL and a total growth inhibition at concentrations above 625 μg/mL.
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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