Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/25178
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Campo DC | Valor | Idioma |
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dc.contributor.author | Costa, Rui R. | - |
dc.contributor.author | Castro Otero, Emilio | - |
dc.contributor.author | Arias, F. J. | - |
dc.contributor.author | Rodríguez-Cabello, José Carlos | - |
dc.contributor.author | Mano, J. F. | - |
dc.date.accessioned | 2013-09-17T13:26:39Z | - |
dc.date.available | 2013-09-17T13:26:39Z | - |
dc.date.issued | 2013-05 | - |
dc.date.submitted | 2013-05 | - |
dc.identifier.issn | 1525-7797 | por |
dc.identifier.uri | https://hdl.handle.net/1822/25178 | - |
dc.description.abstract | Inspired by the cells’ structure, we present compartmentalized capsules with temperature and magnetic-based responsiveness and hierarchical organization ranging from the nano- to the visible scales. Liquefied alginate macroscopic beads coated with a layer-by-layer (LbL) chitosan/alginate shell served as containers both for model fluorophores and microcapsules, which in their turn encapsulated either another fluorophore or magnetic nanoparticles (MNPs). The microcapsules were coated with a temperature-responsive chitosan/elastin-like recombinamer (ELR) nanostructured shell. By varying the temperature from 25 to 37 °C, the two-hour release of rhodamine encapsulated within the microcapsules and its diffusion through the external compartment decreased from 84% and 71%. The devices could withstand handling and centrifugal stress, with 50% remaining intact at a rotation speed of 2000g. MNPs attributed magnetic responsiveness toward external magnetic fields. Such a customizable system can be envisaged to transport bioactive agents and cells in tissue engineering applications. | por |
dc.description.sponsorship | The authors are grateful for financial support from Fundacao para a Ciencia e Tecnologia (Grant SFRH/BD/61126/2009), "Fundo Social Europeu", "Programa Diferencial de Potencial Humano", EU seventh Framework Programme (No. RE-GPOT-CT2012-316331-POLARIS), Health and Progress Foundation (Mobility Program for Nanomedicine), Andalusian Initiative for Advanced Therapies (Ministry of Health of the Andalusian Regional Government), EC (FP7-Health-2011 No. 278557 "The Grail", FP7-NMP-2010 No. 263363 "Innova-Bone"), MEC of the Spanish Government (MAT2012-38043-C02-01, MAT2010-15310, MAT-2010-15982, PRI-PIBAR-2011-1403, ACI2009-0890), JCyL (VA155A12-2, VA152A12-2, VA049A11-2), Network Center of Regenerative Medicine and Cellular Therapy of Castilla y Leon funded by the JCyL and the ISCIII, and CIBER-BBN funded by the ISCIII. | por |
dc.language.iso | eng | por |
dc.publisher | American Chemical Society | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F61126%2F2009/PT | - |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/316331/EU | - |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/278557/EU | - |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/263363/EU | - |
dc.rights | restrictedAccess | por |
dc.subject | Compartments | por |
dc.subject | Hierarchical organization | por |
dc.subject | Magnetic properties | por |
dc.subject | Multilayers | por |
dc.subject | Polymers | por |
dc.title | Multifunctional Compartmentalized Capsules with a Hierarchical Organization from the Nano to the Macro Scales | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://pubs.acs.org/doi/abs/10.1021/bm400527y | por |
dc.comments | http://www.3bs.uminho.pt/node/17546 | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 2403 | por |
oaire.citationEndPage | 2410 | por |
oaire.citationIssue | 7 | por |
oaire.citationTitle | Biomacromolecules | por |
oaire.citationVolume | 14 | por |
dc.date.updated | 2013-07-16T14:53:09Z | - |
dc.identifier.doi | 10.1021/bm400527y | por |
dc.identifier.pmid | 23692358 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Biomacromolecules | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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17546-bm400527y.pdf Acesso restrito! | 4,49 MB | Adobe PDF | Ver/Abrir |