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TitleIn vitro induction of melanin synthesis and extrusion by tamoxifen
Author(s)Matamá, Maria Teresa
Araújo, Rita
Preto, Ana
Paulo, Artur Cavaco
Gomes, A. C.
Cell culture
Skin pigmentation
Genetic analysis
Colour cosmetics
Issue dateMay-2013
JournalInternational Journal of Cosmetic Science
Abstract(s)Physical appearance has significant importance psychologically and socially, with skin and hair being of prime relevance. Effective ingredients that modulate melanin synthesis are of growing interest. Tamoxifen, a widely used selective oestrogen receptor modulator, SERM, was described occasionally in medical case reports as causing grey hair repigmentation. This work aimed to study, in vitro, the effect of tamoxifen and 4-hydroxy-tamoxifen, one of its most bioactive derivatives, on melanin production in human melanocytes.
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series
DBio - Artigos/Papers

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