Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/24288

TitlePolymeric nanogels as vaccine delivery systems
Author(s)Ferreira, Sílvia A.
Gama, F. M.
Vilanova, Manuel
KeywordsAdjuvants
Delivery systems
Polymeric nanogels
Vaccines
Issue date2013
PublisherElsevier
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Abstract(s)Polymeric nanogels find a relevant field of application in the formulation of a new generation of therapeutic and preventive vaccines, aiming at the fine-tuned modulation of the immune response. Intrinsic properties of polymeric nanogels, such as material chemistry, size and shape, surface charge, and hydrophobicity or hydrophilicity, may be determining factors in shaping the induced immune response. These materials can thus work as synthetic adjuvants, which can also be conjugated with immunostimulants. Polymeric nanogels protect vaccine antigens from degradation in vivo and, surface-conjugated with antibodies or specific ligands, could increase active targeting specificity. This review covers the recent published data concerning the modulation of innate and adaptive immune responses by engineered polymeric nanogels and their potential application as delivery systems in vaccination.
TypeArticle
URIhttp://hdl.handle.net/1822/24288
DOI10.1016/j.nano.2012.06.001
ISSN1549-9634
e-ISSN1549-9642
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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