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TitleDevelopment of marine-based nanocomposite scaffolds for biomedical applications
Author(s)Reys, L. L.
Silva, Simone Santos
Boutinguiza, M.
Comesaña, R.
Lusquiños, F.
Pou, J.
Mano, J. F.
Silva, Tiago H.
Reis, R. L.
KeywordsNanocomposite scaffolds
Squid chitosan
Tissue engineering
Issue dateSep-2012
JournalJournal of Tissue Engineering and Regenerative Medicine
CitationReys L. L., Silva S. S., Boutinguiza S. S., Comesana M., Lusquinos R., Pou J., Mano J. F., Silva T. H., Reis R. L. Development of marine-based nanocomposite scaffolds for biomedical applications, 3rd Termis World Congress 2012, 2012
Abstract(s)Despite the increasing attention that marine organisms are receiving, many of those are not efficiently exploited and subproducts with valuable compounds are being discarded. Two examples of those subproducts are the endoskeleton of squid, from which β-­‐chitin and consecutively chitosan can be obtained; and fish-­‐bones, as a source for the production of nano-­‐ hydroxyapatite. In this work, inspired in the nanocomposite structure of human bone, marine-­‐ based nanocomposite scaffolds composed by chitosan and nano-­‐hydroxyapatite (nHA) were developed using particle aggregation methodology. Chitosan was obtained from endoskeleton of giant squid Dosidicus Gigas while fish hydroxyapatite nanoparticles were synthesized from fish-­‐bones by pulsed laser in deionized water. An innovative methodology was used based on the agglomeration of prefabricated microspheres of chitosan/nHA, generally based on the random packing of microspheres with further aggregation by physical or thermal means to create a marine nanocomposite (CHA) .The morphological analysis of the developed nanocomposites revealed a low porosity structure, but with high interconnectivity, for all produced scaffolds. Furthermore, the nanocomposite scaffolds were characterized in terms of their mechanical properties, bioactivity, crystallinity and biological behavior. The obtained results highlight that the chitosan/nHA-­‐based marine nanocomposite can be a good candidate for biomedical applications, namely on bone regeneration.
AccessOpen access
Appears in Collections:3B’s - Resumos em livros de atas de conferências - indexados no ISI Web of Science

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