Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/23762
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Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Costa, Rui R. | - |
dc.contributor.author | Neto, Ana I. | - |
dc.contributor.author | Calgeris, I. | - |
dc.contributor.author | Correia, Clara R. | - |
dc.contributor.author | Pinho, A. C. Marques de | - |
dc.contributor.author | Fonseca, Jaime C. | - |
dc.contributor.author | Öner, E. T. | - |
dc.contributor.author | Mano, J. F. | - |
dc.date.accessioned | 2013-04-22T11:16:14Z | - |
dc.date.available | 2013-04-22T11:16:14Z | - |
dc.date.issued | 2013-03 | - |
dc.date.submitted | 2013-04 | - |
dc.identifier.issn | 2050-750X | por |
dc.identifier.uri | https://hdl.handle.net/1822/23762 | - |
dc.description.abstract | Medical adhesives and sealants often require that long-term adhesiveness is achieved. In this work, nanostructured coatings consisting of chitosan and the adhesive bacterial exopolysaccharide levan are fabricated using layer-by-layer (LbL) assembly. Taking advantage of the electrostatic self-assembly mechanism of LbL, the charges of both chitosan and a phosphonate-derivatized levan (Ph-levan) are measured and the feasibility to construct hybrid films is monitored and confirmed using a quartz crystal microbalance with dissipation monitoring (QCM-D). The adhesive properties between two identical bonded films with a total of 100 layers are compared to control films in which Ph-levan is replaced by alginate, revealing that the detachment force of the former is about 3 times higher than the control. Scanning electron microscopy of the films surface shows that the surface of Ph-levan films is smooth and homogeneous. Cell adhesion tests were conducted using a L929 cell line. Early cell adhesion is significantly higher in chitosan/Ph-levan films when compared to chitosan/alginate controls. These findings establish levan derivatives as bioinspired ingredients for conceiving medical adhesive devices that allow achieving enhanced mechanical and biological performance. | por |
dc.description.sponsorship | This work was carried out under the scope of Fundacao para a Ciencia e Tecnologia" - FCT (grants SFRH/BD/61126/2009, SFRH/BD/73119/2010 and SFRH/BD/69529/2010), "Fundo Social Europeu" - FSE, "Programa Diferencial de Potencial Humano" - POPH, COST Action TD0906, and the financial support provided by TUBITAK through Project no.: 111M232. | por |
dc.language.iso | eng | por |
dc.publisher | Royal Society of Chemistry | por |
dc.rights | restrictedAccess | por |
dc.subject | Adhesives | por |
dc.subject | Biomaterials | por |
dc.subject | Extremophilic polymers | por |
dc.subject | Layer-by-layer | por |
dc.title | Adhesive nanostructured multilayer films using a bacterial exopolysaccharide for biomedical applications | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://pubs.rsc.org/en/content/articlelanding/2013/TB/C3TB20137F | por |
dc.comments | http://www.3bs.uminho.pt/node/17461 | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 2367 | por |
oaire.citationEndPage | 2374 | por |
oaire.citationIssue | 18 | por |
oaire.citationTitle | Journal of Materials Chemistry B | por |
oaire.citationVolume | 18 | por |
dc.date.updated | 2013-04-17T15:42:08Z | - |
dc.identifier.doi | 10.1039/c3tb20137f | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Journal of Materials Chemistry B | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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17461-o36p_RCosta_LevanLbLcoatings_JMatChemB_2013.pdf Acesso restrito! | 390,38 kB | Adobe PDF | Ver/Abrir |