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TitleUnleashing the potential of supercritical fluids for polymer processing in tissue engineering and regenerative medicine
Author(s)Duarte, Ana Rita C.
Santo, Vitor E.
Alves, A.
Silva, Simone Santos
Moreira-Silva, Joana
Silva, Tiago H.
Marques, A. P.
Gomes, Manuela E.
Sousa, R. A.
Mano, J. F.
Reis, R. L.
Natural polymers
Phase inversion
Supercritical fluids
Tissue engineering
Supercritical fluid drying
Issue dateFeb-2013
JournalThe Journal of Supercritical Fluids
Abstract(s)One of the major scientific challenges that tissue engineering and regenerative medicine (TERM) faces to move from benchtop to bedside regards biomaterials development, despite the latest advances in polymer processing technologies. A variety of scaffolds processing techniques have been developed and include solvent casting and particles leaching, compression molding and particle leaching, thermally induced phase separation, rapid prototyping, among others. Supercritical fluids appear as an interesting alternative to the conventional methods for processing biopolymers as they do not require the use of large amounts of organic solvents and the processes can be conducted at mild temperatures. However, this processing technique has only recently started to receive more attention from researchers. Different processing methods based on the use of supercritical carbon dioxide have been proposed for the creation of novel architectures based on natural and synthetic polymers and these will be unleashed in this paper.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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