Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/23321

TítuloDevelopment of nanofiber-reinforced hydrogel scaffolds for nucleus pulposus regeneration by a combination of electrospinning and spraying technique
Autor(es)Thorvaldsson, A.
Correia, Joana Silva
Oliveira, Joaquim M.
Reis, R. L.
Gatenholm, P.
Walkenström, P.
Palavras-chaveElectrospinning
Hydrogels
Spraying technique
DataAbr-2013
EditoraWiley
RevistaJournal of Applied Polymer Science
Resumo(s)In this work a new method is presented to efficiently produce hydrogel scaffolds reinforced with nanofibers to show enhanced mechanical properties and improved structural integrity. The method is based on a combination of air brush spraying of a hydrogel and electrospinning of nanofibers. With air brush spraying the controllability is enhanced and the potential for scale-up increased. The developed method was used to successfully reinforce gellan gum hydrogels with electrospun polycaprolactone nanofibers. Optical and rheological evaluations were performed and showed that parameters such as the amount of incorporated nanofibers, gellan gum concentration and calcium chloride (crosslinker) concentrations could be used to modulate material properties. Incorporation of a small amount of nanofibers had a reinforcing effect and resulted in a hydrogel with rheological properties similar to the human nucleus pulposus (NP). The method is flexible and carries potential for designing scaffolds for e.g. NP tissue regeneration.
Tipoarticle
URIhttp://hdl.handle.net/1822/23321
Versão da editorahttp://onlinelibrary.wiley.com/doi/10.1002/app.38316/full
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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