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|Título:||Aluminum-free glass-ionomer bone cements with enhanced bioactivity and biodegradability|
|Autor(es):||Gomes, Filipa Oliveira|
Pires, R. A.
Reis, R. L.
|Revista:||Materials Science and Engineering: C|
|Resumo(s):||Al-free glasses of general composition 0.340SiO2:0.300ZnO:(0.250-a-b)CaO:aSrO:bMgO:0.050Na2O:0.060P2O5 (a, b=0.000 or 0.125) were synthesized by melt quenching and their ability to form glass-ionomer cements was evaluated using poly(acrylic acid) andwater.We evaluated the influence of the poly(acrylic acid)molecular weight and glass particle size in the cementmechanical performance.Higher compressive strength (25±5 MPa) and higher compressive elasticmodulus (492±17 MPa) were achieved with a poly(acrylic acid) of 50 kDa and glass particle sizes between 63 and 125 μm. Cements prepared with glass formulation a=0.125 and b=0.000 were analyzed after immersion in simulated body fluid; they presented a surface morphology consistent with a calcium phosphate coating and a Ca/P ratio of 1.55 (similar to calcium-deficient hydroxyapatite). Addition of starch to the cement formulation induced partial degradability after 8 weeks of immersion in phosphate buffer saline containing α-amylase. Micro-computed tomography analysis revealed that the inclusion of starch increased the cement porosity from 35% to 42%. We were able to produce partially degradable Al-free glass-ionomer bone cements with mechanical performance, bioactivity and biodegradability suitable to be applied on non-load bearing sites and with the appropriate physical characteristics for osteointegration upon partial degradation. Zn release studies (concentrations between 413 μM and 887 μM) evidenced the necessity to tune the cement formulations to reduce the Zn concentration in the surrounding environment.|
|Versão da editora:||http://www.sciencedirect.com/science/article/pii/S0928493112005942|
|Aparece nas coleções:||3B’s - Artigos em revistas/Papers in scientific journals|
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|Materials Science and Engineering C, 33 (2013), 1361-1370.pdf||1,32 MB||Adobe PDF||Ver/Abrir Solicitar cópia ao autor!|