Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/22647

TitleInfluence of fiber diameter and crystallinity on the stability of electrospun poly(L-lactic acid) membranes to hydrolytic degradation
Author(s)Dias, J. C.
Ribeiro, C.
Sencadas, Vítor João Gomes Silva
Botelho, Gabriela
Gómez Ribelles, J. L.
Lanceros-Méndez, S.
KeywordsPoly (L-lactic acid)
Electrospun nanofibers
In-vitro degradation
Viscosity average molecular weight
Issue dateSep-2012
PublisherElsevier
JournalPolymer Testing
Abstract(s)Hydrolytic degradation of electrospun mats of poly(L-lactic acid), PLLA, as a function of crystallinity and fiber diameter has been studied. The degradation in a saline phosphate buffer solution (PBS) up to 20 weeks produced a slight decrease in the sample mass but a clear decrease of the polymer average molecular weight in the amorphous fibers. The aforementioned effect decreases as crystallinity increases. Important for applications is that morphological characteristics of the membranes such as average fiber diameter and membrane porosity are also affected by the degradation process. Fiber diameter increases while membrane porosity decreases, resulting in closer packed fibers due to the release of internal tensions related to the electrospinning and/or thermal treatment processes.
TypeArticle
URIhttp://hdl.handle.net/1822/22647
DOI10.1016/j.polymertesting.2012.05.007
ISSN0142-9418
Publisher versionhttp://ac.els-cdn.com/S014294181200092X/1-s2.0-S014294181200092X-main.pdf?_tid=e6e8181c-5f45-11e2-b853-00000aacb35e&acdnat=1358276640_e6a313d60cab80beeab0e959c69446cb
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:CDF - FCD - Artigos/Papers (with refereeing)

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