Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/22614

TitleWound-healing evaluation of entrapped active agents into protein microspheres over cellulosic gauzes
Author(s)Silva, Raquel
Ferreira, Helena
Matamá, Maria Teresa
Gomes, Andreia
Paulo, Artur Cavaco
KeywordsGauzes
Inflammation
Non-steroidal anti-inflammatory drugs
Protein microspheres
Wound healing
Issue date2012
PublisherWiley
JournalBiotechnology Journal
Abstract(s)The use of active ingredients in wound management have evolved alongside the pharmaceutical agents and dressings used to deliver them. However, the development of gauzes, dressings with specific properties, still remains a challenge for several medical applications. A new methodology for the controlled release of active components for the healing of burn wounds is proposed herein. Cotton and non-woven bandages have been cationised to promote the attachment of protein microspheres. The active agents, piroxicam and vegetable oil, were entrapped into the microspheres using ultrasound energy. Active agents were released from the microspheres by a change in pH. Wound healing was assessed through the use of standardised burn wounds induced by a cautery in human full-thickness skin equivalents (EpidermFT). The best re-epithelialisation and fastest wound closure was observed in wounds treated with proteinaceous microspheres attached to gauzes, after six days of healing, in comparison with commercial collagen dressing and other controls. Furthermore, the ability of these materials to reduce the inflammation process, together with healing improvement, makes these biomaterials suitable for wound-dressing applications.
TypeArticle
URIhttp://hdl.handle.net/1822/22614
DOI10.1002/biot.201200142
ISSN1860-7314
Publisher versionhttp://dx.doi.org/10.1002/biot.201200142
Peer-Reviewedyes
AccessOpen access
Appears in Collections:DET/2C2T - Artigos em revistas internacionais com arbitragem científica

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