Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/22423

TitleHighly diastereoselective synthesis of aza-diels-alder reaction of danishefsky diene wiht glyoxylate imines
Author(s)Goth, Albertino João Brito
Alves, M. José
Rodríguez-Borges, José E.
Issue date2012
PublisherSociedade Portuguesa de Química (SPQ)
Abstract(s)Aza-Diels-Alder reaction is an exceptionally powerful synthetic method for the construction of six-membered nitrogen-heterocycles.[1-3] The reaction of Danishefsky's diene 1 with iminoacetates 2 (imines of glyoxylates) provides a convenient protocol for the synthesis of pipiridone adducts 3 (Scheme 1). In this context, we have performed the synthesis of various cycloadducts, precursors of a wide variety of chiral piperidines with potential use as non-natural amino acids or as precursors of biologically active compounds, including iminosugars (glycomimetics).
TypeAbstract
URIhttp://hdl.handle.net/1822/22423
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CDQuim - Comunicações e Proceedings

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