Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/22372

TitleComputational approaches to standard-compliant biofilm data for reliable analysis and integration
Author(s)Sousa, Ana Margarida
Ferreira, Andreia
Azevedo, N. F.
Pereira, Maria Olívia
Lourenço, Anália
Issue date2012
PublisherDe Gruyter Open
JournalJournal of Integrative Bioinformatics
Abstract(s)The study of microorganism consortia, also known as biofilms, is associated to a number of applications in biotechnology, ecotechnology and clinical domains. Nowadays, biofilm studies are heterogeneous and data-intensive, encompassing different levels of analysis. Computational modelling of biofilm studies has become thus a requirement to make sense of these vast and ever-expanding biofilm data volumes. The rationale of the present work is a machine-readable format for representing biofilm studies and supporting biofilm data interchange and data integration. This format is supported by the Biofilm Science Ontology (BSO), the first ontology on biofilms information. The ontology is decomposed into a number of areas of interest, namely: the Experimental Procedure Ontology (EPO) which describes biofilm experimental procedures; the Colony Morphology Ontology (CMO) which characterises morphologically microorganism colonies; and other modules concerning biofilm phenotype, antimicrobial susceptibility and virulence traits. The overall objective behind BSO is to develop semantic resources to capture, represent and share data on biofilms and related experiments in a regularized fashion manner. Furthermore, the present work also introduces a framework in assistance of biofilm data interchange and analysis – BiofOmics (http://biofomics.org) – and a public repository on colony morphology signatures – MorphoCol (http://stardust.deb.uminho.pt/morphocol).
TypeArticle
URIhttp://hdl.handle.net/1822/22372
ISSN1613-4516
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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