Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/20589

TítuloDendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies : a review
Autor(es)Oliveira, Joaquim M.
Salgado, A. J.
Sousa, Nuno
Mano, J. F.
Reis, R. L.
Palavras-chaveCentral nervous system
Dendrimers
Drug delivery systems
Regenerative medicine
Tissue engineering
Theranostics
DataSet-2010
EditoraElsevier
RevistaProgress in Polymer Science
Resumo(s)Since the pioneering work dealing with the synthesis and physicochemical aspects of dendrimers, a predictable and tunable set of compositions for therapeutic, scaffolding and imaging systems has been reported. These are well documented, butmanyhot issues should be examined and reviewed. Herein, a review is given on dendritic nanopolymers and their applications that show promise in the field of regenerative medicine. This review begins with a brief overview on research merging nanotechnology and regenerative medicine. Fundamentals of the synthesis and macromolecular structure of dendritic polymers are provided. Dendrimers fulfill the requirements as carriers for gene, nucleic acids, bioactive molecules and peptide/protein delivery aimed at modulate the cells functions, in vitro and in vivo. However, to make use of this potential, toxicological, drug-loading capacity, surface engineering and host–guest chemistries in dendrimers must be addressed and thus are also discussed. We focus on recent work involving dendrimers with applications in tissue engineering and the central nervous system. Due to their innovative character, applications beyond drug delivery systems became possible, namely as scaffolding and chemoattractants for tissue regeneration, and implantable biodegradable nanomaterialbased medical devices integrated with drug delivery functions (theranostics). Finally, we highlight promising areas for further research and comment on how and why dendrimer and dendron technology should be viewed as the next generation of biomaterials for the 21st century.
Tipoarticle
URIhttp://hdl.handle.net/1822/20589
Versão da editorahttp://www.sciencedirect.com/science/article/pii/S1359644604032763
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals
ICVS - Artigos em Revistas Internacionais com Referee

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
file.pdf4,02 MBAdobe PDFVer/Abrir

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu Currículo DeGóis