Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/1986

TitleBiological microsystem for measuring uric acid in biological fluids
Author(s)Minas, Graça
Martins, Júlio S.
Ribeiro, J. C.
Wolffenbuttel, R. F.
Correia, J. H.
KeywordsBio-system
Uric acid
Optical absorption
Issue date2004
PublisherElsevier
JournalSensors and Actuators A: Physical
Citation"Sensors and Actuators A : Physical". ISSN 0924-4247. 110 (2004) 33-38.
Abstract(s)This paper describes a biological microsystem (bio-system) for measuring uric acid concentration in serum, plasma or urine. Its operation is based on optical absorption in a well-defined part of the visible spectrum. The bio-system is composed by two dies: one is fabricated in polystyrene and contains the microchannels and the other is fabricated in a CMOS standard process and contains the photodetector and readout electronics. The uric acid concentration is measured by using a mixture of 14µl of infinity™ uric acid reagent with 0.25µl of sample. The achieved sensitivity is 0.33 mg/dl (±0.6% of the value in urine of a healthy person), with a 1mm lightpath. Using an optical absorption method, a maximum peak at wavelength λ = 494 nm, is detected. This bio-system can be included in the group of low-cost disposable devices for biological fluids analysis.
TypeArticle
URIhttp://hdl.handle.net/1822/1986
DOI10.1016/j.sna.2003.10.049
ISSN0924-4247
Peer-Reviewedyes
AccessOpen access
Appears in Collections:DEI - Artigos em revistas internacionais

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