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TitleBiological microsystem for measuring uric acid in biological fluids
Author(s)Minas, Graça
Martins, Júlio S.
Ribeiro, J. C.
Wolffenbuttel, R. F.
Correia, J. H.
Uric acid
Optical absorption
Issue date2004
JournalSensors and Actuators A: Physical
Citation"Sensors and Actuators A : Physical". ISSN 0924-4247. 110 (2004) 33-38.
Abstract(s)This paper describes a biological microsystem (bio-system) for measuring uric acid concentration in serum, plasma or urine. Its operation is based on optical absorption in a well-defined part of the visible spectrum. The bio-system is composed by two dies: one is fabricated in polystyrene and contains the microchannels and the other is fabricated in a CMOS standard process and contains the photodetector and readout electronics. The uric acid concentration is measured by using a mixture of 14µl of infinity™ uric acid reagent with 0.25µl of sample. The achieved sensitivity is 0.33 mg/dl (±0.6% of the value in urine of a healthy person), with a 1mm lightpath. Using an optical absorption method, a maximum peak at wavelength λ = 494 nm, is detected. This bio-system can be included in the group of low-cost disposable devices for biological fluids analysis.
AccessOpen access
Appears in Collections:DEI - Artigos em revistas internacionais

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