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https://hdl.handle.net/1822/16788
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Campo DC | Valor | Idioma |
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dc.contributor.author | Martins, Margarida Isabel Barros Coelho | - |
dc.contributor.author | Lazzell, Anna L. | - |
dc.contributor.author | Lopez-Ribot, José L.. | - |
dc.contributor.author | Henriques, Mariana | - |
dc.contributor.author | Oliveira, Rosário | - |
dc.date.accessioned | 2012-02-03T14:55:13Z | - |
dc.date.available | 2012-02-03T14:55:13Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0233-111X | por |
dc.identifier.uri | https://hdl.handle.net/1822/16788 | - |
dc.description.abstract | Candida albicans supernatants contain a mixture of autoregulatory alcohols. In vitro, when added individually or in combination, these alcohols inhibit the yeast to filamentous form conversion. Here we evaluate the in vivo effect of the exogenous administration of a Cocktail solution simulating the composition of alcohols present in a C. albicans culture supernatant(1 ml; 94 μmol l–1 isoamyl alcohol, 70 μmol l–1 2-phenylethanol, 3.2 n mol l–1 E-nerolidol, and 18 n mol l–1 E,E-farnesol) using the well established murine model of hematogenously disseminated candidiasis. Mice injected intraperitoneally with the Cocktail solution demonstrated increased survival and decreased organ fungal burden compared to control mice. Histological observations suggest that the Cocktail, to some extent, has an inhibitory effect on cell filamentation within the kidney. These findings suggest that the exogenous administration of C. albicans autoregulatory alcohols displays a protective effect during disseminated candidiasis. | por |
dc.description.sponsorship | M. M. was financially supported by a fellowship from Fundacao para a Ciencia e Tecnologia, Portugal (contracts SFRH/BD/28222/2006 and SFRH/BPD/73663/2010), co-financed by the Programa Operacional Potencial Humano (POPH)/Fundo Social Europeu (FSE). Work in the laboratory of J.L.L.-R. is supported by grant number R21AI080930 from the National Institute of Allergy and Infectious Diseases. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIAID or the NIH. | por |
dc.language.iso | eng | por |
dc.publisher | Wiley-VCH Verlag | por |
dc.rights | restrictedAccess | por |
dc.subject | Autoregulatory alcohols | por |
dc.subject | Candida albicans | por |
dc.subject | Candidiasis | por |
dc.subject | Murine model | por |
dc.title | Effect of exogenous administration of Candida albicans autoregulatory alcohols in a murine model of hematogenously disseminated candidiasis | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://dx.doi.org/10.1002/jobm.201100158 | - |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 487 | por |
oaire.citationEndPage | 491 | por |
oaire.citationIssue | 4 | - |
oaire.citationTitle | Journal of Basic Microbiology | por |
oaire.citationVolume | 52 | por |
dc.identifier.doi | 10.1002/jobm.201100158 | por |
dc.identifier.pmid | 22052380 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Journal of Basic Microbiology | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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3946.pdf Acesso restrito! | 3,06 MB | Adobe PDF | Ver/Abrir |