Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/16646
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Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Carneiro, Victor Alves | - |
dc.contributor.author | Santos, Hélcio Silva dos | - |
dc.contributor.author | Arruda, Francisco Vassiliepe Sousa | - |
dc.contributor.author | Bandeira, Paulo Nogueira | - |
dc.contributor.author | Albuquerque, Maria Rose Jane Ribeiro | - |
dc.contributor.author | Pereira, Maria Olívia | - |
dc.contributor.author | Henriques, Mariana | - |
dc.contributor.author | Cavada, Benildo Sousa | - |
dc.contributor.author | Teixeira, Edson Holanda | - |
dc.date.accessioned | 2012-01-30T09:56:01Z | - |
dc.date.available | 2012-01-30T09:56:01Z | - |
dc.date.issued | 2011-07-04 | - |
dc.date.submitted | 2011-07-04 | - |
dc.identifier.issn | 1420-3049 | por |
dc.identifier.uri | https://hdl.handle.net/1822/16646 | - |
dc.description.abstract | Croton nepetaefolius is a native plant from northeastern Brazil that belongs to the Euphorbiaceae family. The biological action of this plant has been extensively explored, being the secondary metabolites responsible for its properties alkaloids, diterpenes, and triterpenes. This study aimed to evaluate the ability of casbane diterpene (CD), isolated from the ethanolic extract of C. nepetaefolius, to inhibit microbial growth and biofilm formation of several clinical relevant species (bacteria and yeasts). It was found that CD possessed biocidal and biostatic activity against the majority of the species screened, with minimal active concentrations ranging between 125 and 500 µg/mL. In addition, it was observed that biofilm formation was inhibited even when the planktonic growth was not significantly affected. In conclusion, CD showed potential to be a natural tool for the treatment of diseases caused by different infectious microorganisms | por |
dc.description.sponsorship | This study was supported by FUNCAP and CNPq (Brazil) and by FCT (Portugal) through the project PTDC/SAU-ESA/64609/2006. | por |
dc.language.iso | eng | por |
dc.publisher | MDPI | por |
dc.rights | openAccess | por |
dc.subject | Casbane diterpene | por |
dc.subject | Biofilm-associated infections control | por |
dc.subject | Natural antimicrobials | por |
dc.subject | Bacteria and yeast | por |
dc.title | Casbane diterpene as a promising natural antimicrobial agent against biofilm-associated infections | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 190 | por |
oaire.citationEndPage | 201 | por |
oaire.citationIssue | 1 | por |
oaire.citationTitle | Molecules | por |
oaire.citationVolume | 16 | por |
dc.identifier.doi | 10.3390/molecules16010190 | por |
dc.identifier.pmid | 21193844 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Molecules | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |