Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/14355
Título: | Liquefied capsules coated with multilayered polyelectrolyte films for cell immobilization |
Autor(es): | Costa, Nazua P. Sher, Praveen Mano, J. F. |
Palavras-chave: | Liquidfied capsules Layer-by-layer Cell encapsulation |
Data: | 25-Mar-2011 |
Editora: | Wiley-Blackwell |
Revista: | Advanced Engineering Materials |
Resumo(s): | Natural-derived polymers are used to coat liquid-core capsules layer by layer to encapsulate cells. Human osteoblast-like cells (SaOs-2) are encapsulated in such spherical devices using a three-step methodology: i) ionotropic gelation to produce alginate beads encapsulating the cells; ii) layer-by-layer coating using water-soluble chitosan and alginate; and iii) core liquefaction. Cells remain viable for 3 d after the encapsulation procedure, suggesting that the developed capsules possess a semipermeable, nanostructured coating. All of the capsules exhibit a spherical shape, smooth surface and liquid-core characteristics. All of the processes are conducted under mild conditions and physiological pH. We consider that the methodology employed in the development of the capsules obtained from natural-based biomaterials has potential to find applicability in the development of scaffolds or cell carriers in tissue engineering and regenerative medicine. |
Tipo: | Artigo |
Descrição: | NMP4-SL-2009-229292 |
URI: | https://hdl.handle.net/1822/14355 |
DOI: | 10.1002/adem.201080138 |
ISSN: | 1438-1656 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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nauza paper.pdf Acesso restrito! | 501,37 kB | Adobe PDF | Ver/Abrir |