Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/13293

TítuloThe double porogen approach as a new technique for the fabrication of interconnected poly(L-lactic acid) and starch based biodegradable scaffolds
Autor(es)Ghosh, Satyabrata
Viana, J. C.
Reis, R. L.
Mano, J. F.
Data2007
EditoraSpringer
RevistaJournal of Materials Science: Materials in Medicine
Resumo(s)One of the most widely used fabrication methods of three dimensional porous scaffolds involves compression moulding of a polymer salt mixture, followed by salt leaching. However, the scaffolds prepared by this technique have typically limited interconnectivity. In this study, besides salt particles, an additional polymeric porogen, poly(ethylene oxide), PEO, was added to poly(L-lactic acid), PLLA, to enhance the interconnectivity of the scaffolds. Compression moulded specimens were quenched and put intowater, where PEO crystallized and phase separated. Following the leaching of PEO fraction, the permeability and interconnectivity among the macropores formed by salt leaching could be observed. The porosities obtained in the prepared scaffolds were between 76 to 86%. Moreover, the highest porosity of 86% was obtained with minimum fraction of total porogen. The water absorption of the porous scaffolds prepared with PEO could vary between 280 to 450% while water uptake of pure PLLA scaffolds was about 93%. The increase of interconnectivity induced by compounding PLLA with PEO could also be obtained in porous PLLA/starch blends and PLLA/hydroxyapatite composites demonstrating the versatility and wide applicability of this preparation protocol. The simplicity of this organic solvent free preparation procedure of three-dimensional porous scaffolds with high interconnectivity and high surface area to volume ratio holds a promise for several tissue engineering applications.
TipoArtigo
URIhttps://hdl.handle.net/1822/13293
DOI10.1007/s10856-006-0680-y
ISSN0957-4530
Arbitragem científicayes
AcessoAcesso restrito UMinho
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals
IPC - Artigos em revistas científicas internacionais com arbitragem

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
12. The double porogen approach as a new technique for the fabrication of interconnected poly (L-.pdf
Acesso restrito!
724,54 kBAdobe PDFVer/Abrir

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID