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TitleThermoresponsive self-assembled elastin-based nanoparticles for delivery of BMPs
Author(s)Bessa, Paulo C.
Machado, Raul
Nürnberger, Sylvia
Dopler, Daniela
Banerjee, Asmita
Cunha, A. M.
Rodríguez-Cabello, José Carlos
Redl, Heinz
Griensven, Martijn van
Reis, R. L.
Casal, Margarida
KeywordsElastin-like polymer
Issue dateMar-2010
JournalJournal of controlled release
Abstract(s)Elastin-like polymers are a new type of protein-based polymers that display interesting properties in the biomaterial field. Bone morphogenetic proteins (BMPs) are cytokines with a strong ability to promote new bone formation. In this work, we explored the use of elastin-like nanoparticles (average size 237.5±3.0 nm), created by thermoresponsive self-assembly, for the combined release of bone morphogenetic protein-2 (BMP-2) and bone morphogenetic protein-14 (BMP-14). These BMPs could be encapsulated at high efficiency into the elastin-like particles and delivered in a sustained way for 14 days. The activity of the growth factors was retained, as shown by the induction of ALP activity and osteogenic mineralization in C2C12 cells. Increased bioactivity was observed with a combined release of BMP-2 and BMP-14. This approach shows a significant potential for future tissue engineering applications in bone.
Publisher version
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals
IPC - Artigos em revistas científicas internacionais com arbitragem

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