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https://hdl.handle.net/1822/91471
Título: | Exploring the transcriptional landscape of phagehost interactions using novel high-throughput approaches |
Autor(es): | Putzeys, Leena Wicke, Laura Brandão, Ana Catarina Ribeiro Boon, Maarten Pires, Diana Priscila Penso Azeredo, Joana Vogel, Jörg Lavigne, Rob Gerovac, Milan |
Data: | Fev-2024 |
Editora: | Elsevier |
Revista: | Current Opinion in Microbiology |
Citação: | Putzeys, Leena; Wicke, Laura; Brandão, Ana Catarina; Boon, Maarten; Pires, Diana P.; Azeredo, Joana; Vogel, Jörg; Lavigne, Rob; Gerovac, Milan, Exploring the transcriptional landscape of phagehost interactions using novel high-throughput approaches. Current Opinion in Microbiology, 77(102419), 2024 |
Resumo(s): | In the last decade, powerful high-throughput sequencing approaches have emerged to analyse microbial transcriptomes at a global scale. However, to date, applications of these approaches to microbial viruses such as phages remain scarce. Tailoring these techniques to virus-infected bacteria promises to obtain a detailed picture of the underexplored RNA biology and molecular processes during infection. In addition, transcriptome study of stress and perturbations induced by phages in their infected bacterial hosts is likely to reveal new fundamental mechanisms of bacterial metabolism and gene regulation. Here, we provide references and blueprints to implement emerging transcriptomic approaches towards addressing transcriptome architecture, RNARNA and RNAprotein interactions, RNA modifications, structures and heterogeneity of transcription profiles in infected cells that will provide guides for future directions in phage-centric therapeutic applications and microbial synthetic biology. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/91471 |
DOI: | 10.1016/j.mib.2023.102419 |
ISSN: | 1369-5274 |
Versão da editora: | https://www.sciencedirect.com/journal/current-opinion-in-microbiology |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_57746_1.pdf | 1,5 MB | Adobe PDF | Ver/Abrir |