Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/90543
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Leite, Ângela B. M. P. | por |
dc.contributor.author | Martins, Cátia D. F. | por |
dc.contributor.author | Raposo, M. Manuela M. | por |
dc.contributor.author | Costa, Susana P. G. | por |
dc.date.accessioned | 2024-04-03T14:54:31Z | - |
dc.date.available | 2024-04-03T14:54:31Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Leite, A. B. M. P.; Martins, C. D.; Raposo, M. M. M.; Costa, S. P. G. Preparation of a Fluorescent Peptide Substrate to Target Tumor-associated Macrophages. Proceedings of the 27th International Electronic Conference on Synthetic Organic Chemistry. Chem. Proc. 2023, 14(1), 63. | por |
dc.identifier.issn | 2673-4583 | por |
dc.identifier.uri | https://hdl.handle.net/1822/90543 | - |
dc.description.abstract | One of the significant challenges in targeting M2 macrophages is the need for specific and high-affinity targeting ligands that can distinguish them from phenotype M1 macrophages. In order to investigate the selectivity of the polypeptide M2pep (YEQDPWGVKWWY) towards M2 macrophages using fluorescence-based techniques, we report here the synthesis and characteriza-tion of the M2pep substrate labeled with a fluorophore. This peptide comprising a 12-amino acid sequence with a spacer consisting of three additional glycines (GGG) was synthesized and cou-pled to Rhodamine B at its N-terminal via microwave-assisted solid-phase synthesis. The structure of the labeled peptide was confirmed by NMR, UV-Vis, fluorescence spectroscopy and mass spec-trometry. | por |
dc.description.sponsorship | This research was funded by the Foundation for Science and Technology (FCT) who provided financial support to CQ/UM (UID/QUI/00686/2020), project (PTDC/QUI-OUT/3143/2021) and a PhD grant to C. D. F. Martins (SFRH/BD/05277/2020). The NMR spectrometer Bruker Avance III 400 is part of the National NMR Network and was purchased within the framework of the National Program for Scientific Re-equipment, contract REDE/1517/RMN/2005, with funds from POCI 2010 (FEDER) and FCT. | por |
dc.language.iso | eng | por |
dc.publisher | MDPI | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00686%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI-OUT%2F3143%2F2021/PT | por |
dc.relation | SFRH/BD/05277/2020 | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | Fluorescent substrates | por |
dc.subject | M2 macrophages | por |
dc.subject | Peptide labeling | por |
dc.subject | Rhodamine B | por |
dc.subject | Tumor targeting | por |
dc.title | Preparation of a fluorescent peptide substrate to target tumor-associated macrophages | por |
dc.type | conferencePaper | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://doi.org/10.3390/ecsoc-27-16101 | por |
oaire.citationConferenceDate | 15 nov. - 15 dez. 2023 | por |
sdum.event.title | 27th International Electronic Conference on Synthetic Organic Chemistry (ECSOC27) | por |
sdum.event.type | conference | por |
oaire.citationStartPage | 63 | por |
oaire.citationConferencePlace | https://ecsoc-27.sciforum.net/ | por |
dc.identifier.doi | 10.3390/ecsoc-27-16101 | por |
dc.subject.fos | Ciências Naturais::Ciências Químicas | por |
sdum.conferencePublication | Chemistry Proceedings | por |
oaire.version | VoR | por |
dc.subject.ods | Saúde de qualidade | por |
Aparece nas coleções: | CDQuim - Comunicações e Proceedings |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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chemproc-14-00063.pdf | proceeding | 887,7 kB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons