Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/87155

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dc.contributor.authorFernandes, Beatriz Ferreirapor
dc.contributor.authorSilva, Neusapor
dc.contributor.authorMarques, Joana Fariapor
dc.contributor.authorDa Cruz, Mariana Britopor
dc.contributor.authorTiainen, Laura Katariinapor
dc.contributor.authorGasik, Michaelpor
dc.contributor.authorCarvalho, Óscar Samuel Novaispor
dc.contributor.authorSilva, Filipe Samuelpor
dc.contributor.authorCaramês, Joãopor
dc.contributor.authorMata, Antóniopor
dc.date.accessioned2023-10-31T11:59:55Z-
dc.date.available2023-10-31T11:59:55Z-
dc.date.issued2023-08-01-
dc.identifier.citationFernandes, B.F.; Silva, N.; Marques, J.F.; Da Cruz, M.B.; Tiainen, L.; Gasik, M.; Carvalho, Ó.; Silva, F.S.; Caramês, J.; Mata, A. Bio-Piezoelectric Ceramic Composites for Electroactive Implants—Biological Performance. Biomimetics 2023, 8, 338. https://doi.org/10.3390/biomimetics8040338por
dc.identifier.urihttps://hdl.handle.net/1822/87155-
dc.description.abstractBarium titanate (BaTiO<sub>3</sub>) piezoelectric ceramic may be a potential alternative for promoting osseointegration due to its piezoelectric properties similar to bone electric potentials generated in loading function. In this sense, the aim of this in vitro study was to evaluate the cellular response of human osteoblasts and gingival fibroblasts as well as the impact on <i>S. oralis</i> when in contact with BaTiO<sub>3</sub> functionalized zirconia implant surfaces with piezoelectric properties. Zirconia discs with BaTiO<sub>3</sub> were produced and contact poling (piezo activation) was performed. Osteoblasts (hFOB 1.19), fibroblasts (HGF hTERT) and <i>S. oralis</i> were culture on discs. Cell viability and morphology, cell differentiation markers, bacterial adhesion and growth were evaluated. The present study suggests that zirconia composite surfaces with the addition of piezoelectric BaTiO<sub>3</sub> are not cytotoxic to peri-implant cells. Also, they seem to promote a faster initial osteoblast differentiation. Moreover, these surfaces may inhibit the growth of <i>S. oralis</i> by acting as a bacteriostatic agent over time. Although the piezoelectric properties do not affect the cellular inflammatory profile, they appear to enable the initial adhesion of bacteria, however this is not significant over the entire testing period. Furthermore, the addition of non-poled BaTiO<sub>3</sub> to zirconia may have a potential reduction effect on IL-6 mediated-inflammatory activity in fibroblasts.por
dc.description.sponsorshipThis research was funded by FCT project POCI-01-0145-FEDER-030498—Portugal, by FEDER funds through the COMPETE 2020—Programa Operacional Competitividade e Internacionalização (POCI). Partially funded by the Faculty of Dental Medicine of the University of Lisbon Scholarship for Open Access Publications.por
dc.language.isoengpor
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)por
dc.relationPOCI-01-0145-FEDER-030498por
dc.rightsopenAccesspor
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/por
dc.subjectDental implantspor
dc.subjectZirconiapor
dc.subjectPiezoelectric propertiespor
dc.subjectBarium titanatepor
dc.subjectOsteoblastspor
dc.subjectFibroblastspor
dc.titleBio-piezoelectric ceramic composites for electroactive implants—biological performancepor
dc.typearticlepor
dc.peerreviewedyespor
dc.relation.publisherversionhttps://www.mdpi.com/2313-7673/8/4/338por
oaire.citationStartPage1por
oaire.citationEndPage18por
oaire.citationIssue4por
oaire.citationVolume8por
dc.date.updated2023-08-25T12:37:20Z-
dc.identifier.eissn2313-7673-
dc.identifier.doi10.3390/biomimetics8040338por
sdum.journalBiomimeticspor
oaire.versionVoRpor
dc.identifier.articlenumber338por
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