Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/87004
Título: | Chitosan/virgin-coconut-oil-based system enriched with cubosomes: a 3D drug-delivery approach |
Autor(es): | Silva, SS Rodrigues, Luísa Cidália Guimarães Fernandes, Emanuel Mouta Soares da Costa, Diana Villalva, Denise G. Loh, Watson Reis, R. L. |
Palavras-chave: | Chitosan Virgin coconut oil Cubosomes Emulsion system Porous structures Biomedical applications |
Data: | 6-Jul-2023 |
Editora: | Multidisciplinary Digital Publishing Institute (MDPI) |
Revista: | Marine Drugs |
Citação: | Silva, S.S.; Rodrigues, L.C.; Fernandes, E.M.; Soares da Costa, D.; Villalva, D.G.; Loh, W.; Reis, R.L. Chitosan/Virgin-Coconut-Oil-Based System Enriched with Cubosomes: A 3D Drug-Delivery Approach. Mar. Drugs 2023, 21, 394. https://doi.org/10.3390/md21070394 |
Resumo(s): | Emulsion-based systems that combine natural polymers with vegetable oils have been identified as a promising research avenue for developing structures with potential for biomedical applications. Herein, chitosan (CHT), a natural polymer, and virgin coconut oil (VCO), a resource obtained from coconut kernels, were combined to create an emulsion system. Phytantriol-based cubosomes encapsulating sodium diclofenac, an anti-inflammatory drug, were further dispersed into CHT/VCO- based emulsion. Then, the emulsions were frozen and freeze-dried to produce scaffolds. The scaffolds had a porous structure ranging from 20.4 to 73.4 µm, a high swelling ability (up to 900%) in PBS, and adequate stiffness, notably in the presence of cubosomes. Moreover, a well-sustained release of the entrapped diclofenac in the cubosomes into the CHT/VCO-based system, with an accumulated release of 45 ± 2%, was confirmed in PBS, compared to free diclofenac dispersed (80 ± 4%) into CHT/VCO-based structures. Overall, the present approach opens up new avenues for designing porous biomaterials for drug delivery through a sustainable pathway. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/87004 |
DOI: | 10.3390/md21070394 |
e-ISSN: | 1660-3397 |
Versão da editora: | https://www.mdpi.com/1660-3397/21/7/394 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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marinedrugs-21-00394.pdf | 7,79 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons