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https://hdl.handle.net/1822/85584
Título: | A systematic review of the use of bacteriophages for in vitro biofilm control |
Autor(es): | Meneses, Luciana Brandão, Ana Catarina Coenye, Tom Braga, A. C. Pires, Diana Priscila Penso Azeredo, Joana |
Palavras-chave: | Bacteriophages Biofilm In vitro Systematic review |
Data: | 5-Jul-2023 |
Editora: | Springer Nature |
Revista: | European Journal of Clinical Microbiology & Infectious Diseases |
Citação: | Meneses, L., Brandão, A. C., Coenye, T., Braga, A. C., Pires, D. P., & Azeredo, J. (2023, July 5). A systematic review of the use of bacteriophages for in vitro biofilm control. European Journal of Clinical Microbiology & Infectious Diseases. Springer Science and Business Media LLC. http://doi.org/10.1007/s10096-023-04638-1 |
Resumo(s): | Bacteriophages (phages) are very promising biological agents for the prevention and control of bacterial biofilms. However, little is known about the parameters that can influence the efficacy of phages on biofilms. This systematic review provides a summary and analysis of the published data about the use of phages to control pre-formed biofilms in vitro, suggesting recommendations for future experiments in this area. A total of 68 articles, containing data on 605 experiments addressing the efficacy of phages to control biofilms in vitro were included, after a search conducted in Web of Science, Embase, and Medline (PubMed). The data collected from each experiment included information about biofilm growth conditions, phage characteristics, treatment conditions and biofilm reduction. In most cases, biofilms were formed in the surface of microtiter plates (82.5\%); the median time for biofilm formation was 24 h, as is the median treatment duration. Quantification of biofilm biomass (52.6\%), viable cells (25.5\%) and metabolic activity (17.9\\%) were the most common biofilm assessment methods. Correlation analysis revealed that some phage parameters can influence the treatment outcome: higher phage concentrations were strongly associated with improved biofilm control, leading to higher levels of biofilm reduction, and phages with higher burst sizes and shorter latent periods seem to be the best candidates to control biofilms in vitro. However, the great variability of the methodologies used prompts the need for the development of standardized in vitro methodologies to characterize phage/biofilm interactions and to assess the efficacy of phages to control biofilms. |
Tipo: | Artigo |
Descrição: | The online version contains supplementary material available at: https://doi.org/10.1007/s10096-023-04638-1 |
URI: | https://hdl.handle.net/1822/85584 |
DOI: | 10.1007/s10096-023-04638-1 |
ISSN: | 0934-9723 |
Versão da editora: | http://www.springer.com/biomed/medical+microbiology/journal/10096 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_56346_1.pdf | 1,25 MB | Adobe PDF | Ver/Abrir |